Synaptic adhesion molecules in Cadm family at the neuromuscular junction.

Yuko Tanabe; Eriko Fujita; Yukiko K Hayashi; Xinran Zhu; Hermann Lubbert; Yoshihiro Mezaki; Haruki Senoo; Takashi Momoi

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Synaptic adhesion molecules in Cadm family at the neuromuscular junction.

机译：Cadm家族在神经肌肉接头处的突触粘附分子。

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RA175/SynCAM1/Cadm1 (Cadm1), a member of the immunoglobulin superfamily, is a synaptic cell adhesion molecule that has a PDZ-binding motif at the C-terminal region. It promotes the formation of presynaptic terminals and induces functional synapses in the central nervous system. Cadm1-deficient (knockout [KO]) mice show behavioral abnormalities, including excessive aggression and anxiety, but do not show any symptoms of neuromuscular disorder, although neuromuscular junctions (NMJs) have structures similar to synapses. We have examined the expression of members of the Cadm family in the mouse muscle tissues. Cadm4 and Cadm1 were major components of the Cadm family, and Cadm3 was faintly detected, but Cadm2 was not detected by RT-PCR. Cadm4 as well as Cadm1 colocalized with alpha-bungarotoxin at the NMJs and interacted with the multiple PDZ domain protein Mupp1. Cadm4 was expressed in Cadm1-KO mice and might compensate for Cadm1 loss through interactions with Mupp1.

机译：RA175 / SynCAM1 / Cadm1（Cadm1）是免疫球蛋白超家族的成员，是一种突触细胞粘附分子，在C端区域具有PDZ结合基序。它促进突触前末端的形成，并在中枢神经系统中诱导功能性突触。缺乏Cadm1（敲除[KO]）的小鼠表现出行为异常，包括过度攻击和焦虑，但没有显示任何神经肌肉疾病的症状，尽管神经肌肉接头（NMJ）具有类似于突触的结构。我们检查了小鼠肌肉组织中Cadm家族成员的表达。 Cadm4和Cadm1是Cadm家族的主要组成部分，微弱检测到Cadm3，但RT-PCR未检测到Cadm2。 Cadm4以及Cadm1与NMJ处的α-真菌毒素共定位，并与多个PDZ域蛋白Mupp1相互作用。 Cadm4在Cadm1-KO小鼠中表达，可能通过与Mupp1的相互作用补偿Cadm1的丢失。

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《Cell biology international.》 |2013年第7期|共6页
作者
Yuko Tanabe; Eriko Fujita; Yukiko K Hayashi; Xinran Zhu; Hermann Lubbert; Yoshihiro Mezaki; Haruki Senoo; Takashi Momoi;
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正文语种 eng
中图分类细胞生物学;
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1. Synaptic adhesion molecules in Cadm family at the neuromuscular junction. [J] . Yuko Tanabe, Eriko Fujita, Yukiko K Hayashi, Cell biology international. . 2013,第7期

机译：Cadm家族在神经肌肉接头处的突触粘附分子。
2. Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1 [J] . E Fujita, H Dai, Y Tanabe, Cell death & disease. . 2010,第6期

机译：自闭症谱系障碍与突触细胞粘附分子CADM1突变引起的内质网应激有关
3. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. [J] . Furuno T, Ito A, Koma Y, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2005,第11期

机译：生精的Ig超家族/突触细胞粘附分子肥大细胞粘附分子促进与神经的相互作用。
4. MALDI MS Analysis of N-glycan Structures of a Cell Adhesion Molecule, CADM1, in Various Cancer Cells [C] . Mika Sakurai-Yageta, Tomoko Maruyama, Kaoru Kaneshiro, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：MALDI MS分析细胞粘附分子，CADM1，各种癌细胞中的N-聚糖结构
5. Mechanisms of age and diet on the potentiation of synaptic vesicle release at the adult Drosophila neuromuscular junction. [D] . Mahoney, Rebekah E. 2016

机译：年龄和饮食对成人果蝇神经肌肉交界处突触小泡释放增强的机制。
6. Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule CADM1 [O] . E Fujita, H Dai, Y Tanabe, 2010

机译：自闭症谱系障碍与突触细胞粘附分子CADM1突变引起的内质网应激有关
7. Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1 [O] . E Fujita, H Dai, Y Tanabe, 2010

机译：自闭症谱系障碍与突触细胞粘附分子中突变引起的内质网应激相关，CADM1

Synaptic adhesion molecules in Cadm family at the neuromuscular junction.

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