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首页> 外文期刊>Cell biology international. >Immortality of cell lines: challenges and advantages of establishment.
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Immortality of cell lines: challenges and advantages of establishment.

机译：细胞系的永生性：建立的挑战和优势。

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摘要

Cellular immortality happens upon impairment of cell-cycle checkpoint pathways (p53/p16/pRb), reactivation or up-regulation of telomerase enzyme, or upregulation of some oncogenes or oncoproteins leading to a higher rate of cell division.There are also some other factors and mechanisms involved in immortalisation, which need to be discovered. Immortalisation of cells derived from different sources and establishment of immortal cell lines has proven useful in understanding the molecular pathways governing cell developmental cascades in eukaryotic, especially human, cells. After the breakthrough of achieving the immortal cells and understanding their critical importance in the field of molecular biology, intense efforts have been dedicated to establish cell lines useful for elucidating the functions of telomerase, developmental lineage of progenitors, self-renewal potency, cellular transformation, differentiation patterns and some bioprocesses, like odontogenesis. Meanwhile, discovering the exact mechanisms of immortality, a major challenge for science yet, is believed to open new gateways toward understanding and treatment of cancer in the long term. This review summarises the methods involved in establishing immortality, its advantages and the challenges still being faced in this field.
机译：细胞永生发生在细胞周期检查点途径受损（p53 / p16 / pRb），端粒酶的激活或上调，某些癌基因或癌蛋白的上调导致细胞分裂率增高的同时，还有其他一些因素。以及需要永生的机制。来自不同来源的细胞永生化和永生细胞系的建立已被证明有助于理解控制真核细胞，特别是人细胞中细胞发育级联的分子途径。在获得永生细胞并了解其在分子生物学领域的关键意义的突破后，致力于建立可阐明端粒酶功能，祖细胞发育谱系，自我更新潜能，细胞转化，分化模式和一些生物过程，例如牙本质发生。同时，发现永生的确切机制是科学领域的一项重大挑战，相信它将为长期了解和治疗癌症开辟新的途径。这篇综述总结了建立长生不老的方法，它的优点以及在这一领域仍然面临的挑战。

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