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首页> 外文期刊>Cell and Tissue Research >Network-wide dysregulation of calcium homeostasis in Alzheimer's disease
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Network-wide dysregulation of calcium homeostasis in Alzheimer's disease

机译：阿尔茨海默氏病的全网钙稳态失调

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Dysregulation of intracellular Ca2+ homeostasis has been proposed as a common proximal cause of neural dysfunction during aging and Alzheimer's disease (AD). In this context, aberrant Ca2+ signaling has been viewed as a neuronal phenomenon mostly related to the dysfunction of intracellular Ca2+ stores. However, recent data suggest that, in AD, Ca2+ dyshomeostasis is not restricted to neurons but represents a global phenomenon affecting virtually all cells in the brain. AD-related aberrant Ca2+ signaling in astrocytes and microglia, which is activated during the disease, probably contributes profoundly to an inflammatory response that, in turn, impacts neuronal Ca2+ homeostasis and brain function. Based on recent data obtained in vivo and in vitro, we propose that bidirectional interactions between the inflammatory responses of glial cells and aberrant Ca2+ signaling represent a vicious cycle accelerating disease progression.
机译：已经提出细胞内Ca 2+稳态失调是衰老和阿尔茨海默氏病（AD）期间神经功能障碍的常见近端原因。在这种情况下，异常的Ca2 +信号传导已被视为一种神经元现象，主要与细胞内Ca2 +存储功能障碍有关。但是，最近的数据表明，在AD中，Ca2 +异位稳态不仅限于神经元，还代表了影响大脑中几乎所有细胞的全球性现象。在疾病期间激活的星形胶质细胞和小胶质细胞中与AD相关的异常Ca2 +信号传导可能对炎症反应产生深远影响，进而影响神经元Ca2 +稳态和脑功能。基于在体内和体外获得的最新数据，我们建议神经胶质细胞的炎症反应和异常的Ca2 +信号传导之间的双向相互作用代表加速疾病进展的恶性循环。

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