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首页> 外文期刊>Cell and Tissue Research >Expression of SGTA correlates with neuronal apoptosis and reactive gliosis after spinal cord injury.
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Expression of SGTA correlates with neuronal apoptosis and reactive gliosis after spinal cord injury.

机译：SGTA的表达与脊髓损伤后神经元凋亡和反应性神经胶质增生有关。

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摘要

Small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) is a novel TPR-containing protein involved in various biological processes. However, the expression and roles of SGTA in the central nervous system remain unknown. We have produced an acute spinal cord injury (SCI) model in adult rats and found that SGTA protein levels first significantly increase, reach a peak at day 3 and then gradually return to normal level at day 14 after SCI. These changes are striking in neurons, astrocytes and microglia. Additionally, colocalization of SGTA/active caspase-3 has been detected in neurons and colocalization of SGTA/proliferating cell nuclear antigen has been detected in astrocytes and microglial. In vitro, SGTA depletion by short interfering RNA inhibits astrocyte proliferation and decreases cyclinA and cyclinD1 protein levels. SGTA knockdown also reduces neuronal apoptosis. We speculate that SGTA is involved in biochemical and physiological responses after SCI.
机译：富含小谷氨酰胺的四肽重复序列（TPR）的蛋白质α（SGTA）是一种涉及各种生物过程的新型含TPR的蛋白质。但是，SGTA在中枢神经系统中的表达和作用仍然未知。我们在成年大鼠中建立了急性脊髓损伤（SCI）模型，发现SGTA蛋白水平首先显着增加，在SCI后第3天达到峰值，然后在第14天逐渐恢复到正常水平。这些变化在神经元，星形胶质细胞和小胶质细胞中引人注目。另外，已经在神经元中检测到SGTA /活性caspase-3的共定位，并且在星形胶质细胞和小胶质细胞中检测到了SGTA /增殖细胞核抗原的共定位。在体外，短干扰RNA耗尽SGTA可抑制星形胶质细胞增殖并降低cyclinA和cyclinD1蛋白水平。 SGTA组合还可减少神经元凋亡。我们推测SGTA参与了SCI后的生化和生理反应。

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