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首页> 外文期刊>Cell and Tissue Research >Cochlear efferents in developing adult and pathological conditions
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Cochlear efferents in developing adult and pathological conditions

机译：发育中的成人和病理状况的耳蜗传出

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Cochlear activity is regulated by the olivo-cochlear bundle, which originates from the brainstem and projects onto the hair cells and auditory nerve fibers. Two efferent components can be distinguished: the medial and lateral olivo-cochlear efferent originating from the medial, and the lateral nuclei of the superior olivary complex. The input of the efferent systems on hair cells occurs during development and persists in the adult cochlea. Recent studies have shown that the efferent innervations are required to set the activity pattern in developing hair cells and auditory nerve fibers and to protect the synaptic structures in adult cochlea. In addition, efferent innervations undergo plasticity during pathological conditions such as noise-trauma or aging. This review discusses the mechanisms underlying the control of the hair cells and afferent fibers excitability by efferent neurons and their putative role in developing adult and pathological conditions.
机译：耳蜗活动受橄榄耳蜗束的调节，该耳蜗束起源于脑干，并投射到毛细胞和听觉神经纤维上。可以区分两个传出成分：起源于内侧的内侧和外侧耳蜗耳蜗传出，以及上橄榄复合体的外侧核。发芽系统在毛细胞上的输入发生在发育过程中，并持续存在于成年的耳蜗中。最近的研究表明，需要传出神经支配以设定发育中的毛细胞和听觉神经纤维的活动模式并保护成年耳蜗的突触结构。另外，传出的神经支配在诸如噪音创伤或衰老之类的病理状态下经历可塑性。这篇综述讨论了传出神经元控制毛细胞和传入纤维兴奋性的基本机制，以及它们在发展成年和病理性疾病中的假定作用。

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