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首页> 外文期刊>Cell and Tissue Research >Defects in the adherens junction complex (E-cadherin/beta-catenin) in inflammatory bowel disease
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Defects in the adherens junction complex (E-cadherin/beta-catenin) in inflammatory bowel disease

机译：炎症性肠病中粘附连接复合物（E-钙粘蛋白/β-连环蛋白）的缺陷

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摘要

The epithelial monolayer of the intestine is a selective barrier permitting nutrient and electrolyte absorption yet acting to protect the underlying tissue compartments and cellular components from attack and infiltration by antigens, bacteria and bacterial products present in the lumen. Disruption of this barrier has been associated with inflammatory bowel disease (IBD). The adherens junction (AJ), together with tight junctions (TJ) and desmosomes, form an apical junction complex that controls epithelial cell-to-cell adherence and barrier function as well as regulation of the actin cytoskeleton, intracellular signalling pathways and transcriptional regulation. Numerous studies and reviews highlight the responses of TJs to physiological and pathological stimuli. By comparison, the response of AJ proteins, and the subsequent consequences for barrier function, when exposed to the IBD inflammatory milieu, is less well studied. In this review, we will highlight the roles and responses of the AJ proteins in IBD and provide suggestions for future studies. We will also consider recently proposed therapeutic strategies to preserve or restore epithelial barrier functions to prevent and treat IBD.
机译：肠的上皮单层是选择性屏障，其允许营养物和电解质吸收，但仍起到保护下面的组织隔室和细胞成分不受内腔中存在的抗原，细菌和细菌产物侵袭和渗透的作用。该屏障的破坏与炎症性肠病（IBD）有关。粘附连接（AJ）与紧密连接（TJ）和桥粒一起形成了一个顶点连接复合体，该复合体控制上皮细胞间粘附和屏障功能以及肌动蛋白细胞骨架的调节，细胞内信号通路和转录调节。大量研究和评论强调了TJ对生理和病理刺激的反应。相比之下，当暴露于IBD炎症环境时，AJ蛋白的反应以及对屏障功能的后续后果的研究较少。在这篇综述中，我们将重点介绍AJ蛋白在IBD中的作用和应答，并为以后的研究提供建议。我们还将考虑最近提出的保留或恢复上皮屏障功能以预防和治疗IBD的治疗策略。

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