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首页> 外文期刊>Cell biology international. >Low concentration of oxidant and nitric oxide donors stimulate proliferation of human endothelial cells in vitro.
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Low concentration of oxidant and nitric oxide donors stimulate proliferation of human endothelial cells in vitro.

机译:低浓度的氧化剂和一氧化氮供体在体外刺激人内皮细胞增殖。

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摘要

Proliferation of human umbilical vein endothelial cells in vitro was inhibited by high concentrations of oxidants and nitric oxide donors but stimulated by low (micromolar or submicromolar) concentrations of hydrogen peroxide, menadione, tert-butyl hydroperoxide, AAPH, nitroglycerin, SIN-1 and sodium nitroprusside. The stimulation seems to be dependent upon generation of secondary reactive oxygen species as inferred from attenuation of cell proliferation by superoxide dismutase and catalase. These results point to another type of possible artefact of cell culture, viz. stimulation of cell proliferation by low concentrations of oxidants.
机译:高浓度的氧化剂和一氧化氮供体抑制了体外人脐静脉内皮细胞的增殖,但过低的(微摩尔或亚微摩尔)过氧化氢,甲萘醌,氢过氧化叔丁基,AAPH,硝酸甘油,SIN-1和钠刺激了内皮细胞的增殖。硝普钠。从超氧化物歧化酶和过氧化氢酶抑制细胞增殖可以推断出,刺激似乎取决于次级活性氧的产生。这些结果表明细胞培养的另一种可能的假象,即。低浓度氧化剂刺激细胞增殖。

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