GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation

Wang Fang; Li Zhaotao; Li Leike; Hu Longbo; Xiao Jing; Su Zhong; Peng Tao

首页> 外文期刊>Cell biology international. >GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation

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GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation

机译：GP73在ConA刺激的PBMC中上调，但未能促进淋巴细胞增殖

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Golgi protein 73-kD (GP73), a type II Golgi transmembrane glycoprotein, is highly expressed in a variety of human diseases, but its physiology and pathology remain unknown. In examining the function of GP73 in the immune system, treatment of human PBMC with ConA significantly increased the intracellular expression of GP73 and its secretion into the culture medium. Two-way MLR and the ConA stimulation assay showed that treatment with purified GP73 protein barely affected the proliferation of PBMC. These results suggest that lymphocyte-secreted GP73 might partially contribute to higher serum GP73 in patients, and secreted GP73 exerts an extremely weak effect on the proliferation of PBMC ex vivo.

机译：高尔基蛋白73-kD（GP73）是II型高尔基跨膜糖蛋白，在多种人类疾病中高度表达，但其生理学和病理学仍然未知。在检查GP73在免疫系统中的功能时，用ConA处理人PBMC可显着增加GP73的细胞内表达及其向培养基中的分泌。双向MLR和ConA刺激分析表明，纯化的GP73蛋白处理几乎不影响PBMC的增殖。这些结果表明，淋巴细胞分泌的GP73可能部分地导致患者血清GP73升高，而分泌的GP73对PBMC离体增殖的作用极弱。

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《Cell biology international.》 |2015年第3期|共7页
作者
Wang Fang; Li Zhaotao; Li Leike; Hu Longbo; Xiao Jing; Su Zhong; Peng Tao;
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正文语种 eng
中图分类细胞生物学;
关键词
GP73; ConA; PBMC proliferation;

机译：GP73;ConA;PBMC增殖;

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1. GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation [J] . Wang Fang, Li Zhaotao, Li Leike, Cell biology international. . 2015,第3期

机译：GP73在ConA刺激的PBMC中上调，但未能促进淋巴细胞增殖
2. Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 afterEscherichiacoliLPS Stimulation of PHA-Cultured PBMCs [J] . PanagiotisSkendros, AlexandrosSarantopoulos, KonstantinosTselios, Developmental Immunology: Journal of Immunology Research . 2008,第2期

机译：慢性布鲁氏菌病患者在PHA培养的PBMC的EscherichiacoliLPS刺激后仍保留表达CD25和CD28的CD4 + T淋巴细胞的低频率
3. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells [J] . Elena Geretti, Hirotsugu Asano, Ayumi Yoshida, Biology Open . 2015,第9期

机译：VEGF-A / NRP1刺激GIPC1和Syx复合物的形成，以促进皮肤癌细胞中RhoA的活化和增殖VEGF-A / NRP1刺激GIPC1和Syx复合物的形成，以促进皮肤癌细胞中的RhoA活化和增殖。 Syx复合物的形成促进皮肤癌细胞中RhoA的活化和增殖
4. Magnetic Exposure System To Stimulate Human Lymphocytes Proliferation [C] . H Perez-Olivas, T Cordova-Fraga, F Gomez-Aguilar, Mexican Symposium on Medical Physics . 2012

机译：磁性曝光系统刺激人淋巴细胞增殖
5. Effects of Environmental Endotoxins and Microgravity on Normal Human Peripheral Blood Mononuclear Cells (PBMCS) (Lymphocytes): Role of ETAS as an Immunomodulation Therapy [D] . Chaganti, Maitreyi. 2019

机译：环境内毒素和微重力对正常人外周血单个核细胞（PBMCS）（淋巴细胞）的影响：ETAS作为免疫调节治疗的作用
6. Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 after Escherichia coli LPS Stimulation of PHA-Cultured PBMCs [O] . Panagiotis Skendros, Alexandros Sarantopoulos, Konstantinos Tselios, 2008

机译：慢性布鲁氏菌病患者在大肠埃希氏菌感染后仍保持低频率的CD4 + T淋巴细胞表达CD25和CD28 PHA培养的PBMC的大肠杆菌LPS刺激
7. Stimulation of Naive Monocytes and PBMCs with Coagulation Proteases Results in Thrombin-Mediated and PAR-1-Dependent Cytokine Release and Cell Proliferation in PBMCs Only [O] . Nieuwenhuizen, L., Falkenburg, W. J. J., Schutgens, R. E. G., 2013

机译：凝血蛋白酶刺激幼稚单核细胞和PBMC仅导致凝血酶介导和依赖PAR-1的细胞因子释放以及仅在PBMC中的细胞增殖

GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation

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