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首页> 外文期刊>Cell and Tissue Research >Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation.
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Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation.

机译：胚胎干细胞中的表观遗传学：多能性和分化的调节。

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Embryonic stem cells (ESC) are pluripotent cells capable of multilineage differentiation into every somatic cell type and therefore must be able to initiate transcription profiles for each of these different cells while maintaining their pluripotent state. Numerous studies have attempted to uncover the basic biology of the ESC and delineate mechanisms of pluripotency, but with limited success. However, recent studies attempting to understand the mechanisms by which gene expression is regulated in ESC have uncovered potential mechanisms that may be vitally important to their pluripotent nature. Epigenetic regulatory mechanisms include covalent modification of histone modification and DNA methylation. Studies have now shown that epigenetic mechanisms are vitally important to the pluripotent nature of ESC and that these mechanisms regulate differentiation. The epigenetic nature of the ESC has been demonstrated to be unique and its characteristics have been strongly linked to the global permissivity of gene expression and pluripotency. Unique mechanisms have also been suggested for the dynamic regulation of differentiation-associated gene expression. Additionally, epigenetic mechanisms have been indicated to play a role in the formation of the pluripotent cells of the inner cell mass in the developing blastocyst.
机译：胚胎干细胞（ESC）是多能细胞，能够多向分化为每种体细胞类型，因此必须能够在维持其多能状态的同时启动这些不同细胞的转录概况。大量研究试图揭示ESC的基本生物学特性并描述多能性机制，但取得的成功有限。然而，最近的尝试试图了解在ESC中调节基因表达的机制的研究发现了潜在的机制，这些机制可能对其多能性至关重要。表观遗传调控机制包括组蛋白修饰和DNA甲基化的共价修饰。现在的研究表明，表观遗传机制对于ESC的多能性至关重要，并且这些机制调节分化。已经证明ESC的表观遗传性质是独特的，并且其特征与基因表达和多能性的整体容许性紧密相关。还已经提出了独特的机制来动态调节分化相关基因的表达。另外，已经表明表观遗传机制在发育中的胚泡中内部细胞团的多能细胞的形成中起作用。

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