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首页> 外文期刊>Letters in Applied Microbiology >Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South Korea
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Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South Korea

机译：从韩国泌尿道感染患者中分离出的泌尿致病性大肠杆菌菌株的系统发生群分布，致病因子和抗药性

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摘要

Urinary tract infections (UTIs) are one of the most common diseases by which humans seek medical help and are caused mainly by uropathogenic Escherichia coli (UPEC). Studying the virulence and antibiotic resistance of UPEC with respect to various phylogenetic groups is of utmost importance in developing new therapeutic agents. Thus, in this study, we analysed the virulence factors, antibiotic resistance and phylogenetic groups among various UPEC isolates from children with UTIs. The phylogenetic analysis revealed that majority of the strains responsible for UTIs belonged to the phylogenetic groups B2 and D. Of the 58 E. coli isolates, 79.31% belonged to group B2, 15.51% to group D, 3.44% to group A and 1.72% to B1. Simultaneously, the number of virulence factors and antibiotic resistance exhibited were also significantly high in groups B2 and D compared to other groups. Among the isolates, 44.8% were multidrug resistant and of that 73% belonged to the phylogenetic group B2, indicating the compatibility of antibiotic resistance and certain strains carrying virulence factor genes. The antibiotic resistance profiling of UPEC strains elucidates that the antimicrobial agents such as chloramphenicol, cefoxitin, cefepime, ceftazidime might still be used in the therapy for treating UTIs.
机译：尿路感染（UTI）是人类寻求医疗帮助的最常见疾病之一，主要由尿路致病性大肠杆菌（UPEC）引起。在开发新的治疗剂中，研究UPEC对各种系统发生群体的毒力和抗生素抗性至关重要。因此，在这项研究中，我们分析了来自UTI儿童的各种UPEC分离株中的毒力因子，抗生素抗性和系统发生群。系统发育分析表明，负责UTI的大多数菌株属于B2和D系统发育组。在58株大肠杆菌中，B。组占79.31％，D组占15.51％，A组占3.44％，A组占1.72％到B1。同时，与其他组相比，B2和D组的毒力因子数量和抗生素耐药性也显着较高。在分离物中，有44.8％对多药具有抗药性，其中73％属于系统发生组B2，表明抗生素抗性与某些携带毒力因子基因的菌株具有相容性。 UPEC菌株的抗生素耐药性分析说明，诸如氯霉素，头孢西丁，头孢吡肟，头孢他啶等抗菌剂可能仍可用于治疗UTI。

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