NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.

Trubiani O; Salvolini E; Vignini A; DArcangelo C; Di Primio R; Mazzanti L

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NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.

机译：NF-κB和NOS可能在人RPMI-8402细胞凋亡中起作用。

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Apoptosis is a fundamental process that is required for the normal development and functioning of the immune system. It can be induced in different ways depending on cell type and acquired signal. Since the NF-kappaB transcription factor complex is believed to be involved in nitric oxide-induced apoptosis, the aim of this study was to investigate NF-kappaB and nitric oxide synthase (NOS) activity during dimethyl sulphoxide (DMSO)-dependent cell death of RPMI-8402 human pre-T cells. Our results show that NF-kappaB activation is associated with a significant up-regulation of NOS activity and induction of apoptosis. Furthermore, the inhibition and reversal of these effects by parthenolide treatment or DMSO removal indicate that these molecules are directly involved in the progression of cell death.

机译：凋亡是免疫系统正常发育和功能所必需的基本过程。可以根据细胞类型和获取的信号以不同的方式诱导它。由于NF-κB转录因子复合物被认为与一氧化氮诱导的细胞凋亡有关，因此本研究的目的是研究二甲基亚砜（DMSO）依赖性细胞死亡期间的NF-κB和一氧化氮合酶（NOS）活性。 RPMI-8402人pre-T细胞。我们的结果表明，NF-κB激活与NOS活性的显着上调和细胞凋亡的诱导有关。此外，通过单苯三酚处理或DMSO去除对这些作用的抑制和逆转表明这些分子直接参与细胞死亡的进程。

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《Cell biology international.》 |2005年第7期|共8页
作者
Trubiani O; Salvolini E; Vignini A; DArcangelo C; Di Primio R; Mazzanti L;
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正文语种 eng
中图分类细胞生物学;
关键词
Not free of; Apoptosis; Human; Role; Play; 脱噬作用; 角色;

机译：Not free of;Apoptosis;Human;Role;Play;脱噬作用;角色;

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专利

1. NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis. [J] . Trubiani O, Salvolini E, Vignini A, Cell biology international. . 2005,第7期

机译：NF-κB和NOS可能在人RPMI-8402细胞凋亡中起作用。
2. NF-kappaB plays a major role in the maturation of human dendritic cells induced by NiSO(4) but not by DNCB. [J] . Ade N, Antonios D, Kerdine-Romer S, Toxicological sciences: An official journal of the Society of Toxicology . 2007,第2期

机译：NF-κB在由NiSO（4）而非DNCB诱导的人类树突状细胞成熟中起主要作用。
3. Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role. [J] . Utsugi M, Dobashi K, Ishizuka T, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第7期

机译：Rac1负调控人类巨噬细胞和树突状细胞中脂多糖诱导的IL-23 p19表达，而NF-κBp65反式激活发挥了新的作用。
4. Intermedilysin plays a key role in the invasion of human cells by Streptococcus intermedium [C] . Hideaki Nagamune, Akiko Sukeno, Robert A. Whiley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：含有链球菌中脑膜侵袭人体细胞的关键作用
5. The role of NF-kappaB in mature T lymphocyte function and apoptosis. [D] . Zheng, Ye. 2003

机译：NF-κB在成熟T淋巴细胞功能和凋亡中的作用。
6. Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. [O] . A G Bassuk, R T Anandappa, J M Leiden 1997

机译：Ets与NF-kappaB / NFAT蛋白之间的物理相互作用在T细胞中人类免疫缺陷病毒增强剂的协同激活中起着重要作用。
7. Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by Toll-Like receptor 4, NF-kappaB, and mitogen-activated protein kinases [O] . Bernatoniene, J., Zhang, Q., Dogan, S., 2008

机译：肺炎球菌蛋白肺炎球菌溶血素和Cbpa对人抗原呈递树突状细胞中CC和CXC趋化因子的诱导，以及Toll样受体4，NF-κB和丝裂原活化蛋白激酶的作用

NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.

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