The perivascular niche governs an autoregulatory network to support breast cancer metastasis

FazilatyH.; BehnamB.

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The perivascular niche governs an autoregulatory network to support breast cancer metastasis

机译：血管周围的环境控制着自动调节网络以支持乳腺癌转移

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Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.

机译：揭开诱导并维持癌症干细胞状态的自动调节网络可能会提供针对乳腺癌转移的新型有效疗法。血管周围的环境发展出了一些要素，这些要素启动了自动调节机制，以诱导和维持新到达的肿瘤细胞中的癌症干细胞，而不是EMT。抑制触发该电路的一个或多个主要关键元素可能导致预防或治愈乳腺癌转移。

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《Cell biology international.》 |2014年第6期|共4页
作者
FazilatyH.; BehnamB.;
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正文语种 eng
中图分类细胞生物学;
关键词
Autoregulatory network; Breast cancer metastasis; Cancer stem cell; Epithelial to mesenchymal transition; Transforming growth factor-beta;

机译：自调控网络;乳腺癌转移;癌干细胞;上皮向间质转化;转化生长因子-β;

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专利

1. The perivascular niche governs an autoregulatory network to support breast cancer metastasis [J] . FazilatyH., BehnamB. Cell biology international. . 2014,第6期

机译：血管周围的环境控制着自动调节网络以支持乳腺癌转移
2. Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1 [J] . Huimin Jiang, Chen Zhou, Zhen Zhang, Nature Communications . 2020,第1期

机译：jagged1-notch1部署的肿瘤血管外性质利基通过zeb1促进乳腺癌干细胞表型
3. Understanding the metastatic niche: is breast cancer stem cell dormancy governed by NOTCH signalling? [J] . Santiago-Gomez Angelica, Spina Elena, Spence Kath, Clinical and experimental metastasis . 2017,第8期

机译：理解转移性的利基：乳腺癌干细胞休眠受到缺口信号的治理吗？
4. Regulatory Networks of Integer Nonlinear Programming(RNINLP): a Model to Analyze Gene Regulatory Networks of Breast Cancer Metastasis [C] . Wanchun Luo, Lihong Gong, Kaichun Ren, World Congress on Intelligent Control and Automation;WCICA 2010 . 2010

机译：整数非线性规划（RNINLP）的调控网络：分析乳腺癌转移基因调控网络的模型。
5. Mechanism of Nm23/NDPK in Breast Cancer; Heterologous Signaling in Support of Tumor Angiogenesis and Metastasis [D] . Yokdang, Nucharee 2011

机译：Nm23 / NDPK在乳腺癌中的作用机制；异源信号支持肿瘤血管生成和转移
6. The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo [O] . Gloria Allocca, Russell Hughes, Ning Wang, 2019

机译：乳腺癌的骨转移位可能与体内造血干细胞位重叠
7. Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1 [O] . Huimin Jiang, Chen Zhou, Zhen Zhang, 2020

机译：jagged1-notch1部署的肿瘤血管外性质利基通过zeb1促进乳腺癌干细胞表型

The perivascular niche governs an autoregulatory network to support breast cancer metastasis

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