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首页> 外文期刊>Cell and Tissue Research >Development of the zebrafish myoseptum with emphasis on the myotendinous junction.
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Development of the zebrafish myoseptum with emphasis on the myotendinous junction.

机译：斑马鱼肌隔的发展，着重于肌末端连接。

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Zebrafish myosepta connect two adjacent muscle cells and transmit muscular forces to axial structures during swimming via the myotendinous junction (MTJ). The MTJ establishes transmembrane linkages system consisting of extracellular matrix molecules (ECM) surrounding the basement membrane, cytoskeletal elements anchored to sarcolema, and all intermediate proteins that link ECM to actin filaments. Using a series of zebrafish specimens aged between 24 h post-fertilization and 2 years old, the present paper describes at the transmission electron microscope level the development of extracellular and intracellular elements of the MTJ. The transverse myoseptum development starts during the segmentation period by deposition of sparse and loosely organized collagen fibrils. During the hatching period, a link between actin filaments and sarcolemma is established. The basal lamina underlining sarcolemma is well differentiated. Later, collagen fibrils display an orthogonal orientation and fibroblast-like cells invade the myoseptal stroma. A dense network of collagen fibrils is progressively formed that both anchor myoseptal fibroblasts and sarcolemmal basement membrane. The differentiation of a functional MTJ is achieved when sarcolemma interacts with both cytoskeletal filaments and extracellular components. This solid structural link between contractile apparatus and ECM leads to sarcolemma deformations resulting in the formation of regular invaginations, and allows force transmission during muscle contraction. This paper presents the first ultrastructural atlas of the zebrafish MTJ development, which represents an useful tool to analyse the mechanisms of the myotendinous system formation and their disruption in muscle disorders.
机译：斑马鱼的myosepta连接两个相邻的肌肉细胞，并在游泳过程中通过肌腱接头（MTJ）将肌肉力传递至轴向结构。 MTJ建立了跨膜连接系统，该系统由围绕基底膜的细胞外基质分子（ECM），锚固在肌膜上的细胞骨架元件以及将ECM连接至肌动蛋白丝的所有中间蛋白组成。本文使用一系列在受精后24小时到2岁之间的斑马鱼标本，在透射电子显微镜下描述了MTJ细胞外和细胞内元素的发育。在分割期间，通过稀疏和组织松散的胶原原纤维沉积开始横隔肌隔的发育。在孵化期间，肌动蛋白丝和肌膜之间建立了联系。基底膜下肌膜瘤高度分化。后来，胶原蛋白原纤维表现出正交的方向，成纤维细胞样细胞侵入了肌间隔基质。逐渐形成致密的胶原纤维网络，其锚定肌间隔成纤维细胞和肌膜基底膜。当肌膜与细胞骨架丝和细胞外成分相互作用时，可以实现功能性MTJ的分化。收缩装置和ECM之间的这种牢固的结构联系导致肌膜变形，导致规则的内陷形成，并允许在肌肉收缩过程中传递力。本文介绍了斑马鱼MTJ发展的第一个超微结构图集，它是分析肌腱系统形成机制及其在肌肉疾病中的破坏作用的有用工具。

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