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首页> 外文期刊>Cell and Tissue Research >Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions.
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Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions.

机译：肠道表面的压力：儿茶酚胺和粘膜-细菌相互作用。

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Psychological stress has profound effects on gastrointestinal function, and investigations over the past few decades have examined the mechanisms by which neural and hormonal stress mediators act to modulate gut motility, epithelial barrier function and inflammatory states. With its cellular diversity and large commensal bacterial population, the intestinal mucosa and its overlying mucous environment constitute a highly interactive environment for eukaryotic host cells and prokaryotic bacteria. The elaboration of stress mediators, particularly norepinephrine, at this interface influences host cells engaged in mucosal protection and the bacteria which populate the mucosal surface and gut lumen. This review will address growing evidence that norepinephrine and, in some cases, other mediators of the adaptation to stress modulate mucosal interactions with enteric bacteria. Stress-mediated changes in this delicate interplay may shift the microbial colonization patterns on the mucosal surface and alter the susceptibility of the host to infection. Moreover, changes in host-microbe interactions in the digestive tract may also influence ongoing neural activity in stress-responsive brain areas.
机译：心理应激对胃肠功能具有深远影响，过去几十年的研究已经研究了神经和激素应激介质调节肠蠕动，上皮屏障功能和炎症状态的机制。肠道粘膜及其上层粘液环境具有细胞多样性和大量共生细菌种群，为真核宿主细胞和原核细菌构成了高度互动的环境。在这个界面上，应激介质，特别是去甲肾上腺素的加工，会影响参与黏膜保护的宿主细胞以及在黏膜表面和肠腔中的细菌。这篇综述将解决越来越多的证据，即去甲肾上腺素和某些情况下适应压力的其他介质可调节与肠细菌的粘膜相互作用。应激介导的这种微妙相互作用的变化可能会改变粘膜表面上的微生物定殖模式，并改变宿主对感染的敏感性。此外，消化道中宿主-微生物相互作用的变化也可能影响应激反应性大脑区域中正在进行的神经活动。

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