Glioblastoma stem cells.

Tabatabai G; Weller M

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Glioblastoma stem cells.

机译：胶质母细胞瘤干细胞。

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Glioblastomas are highly malignant primary brain tumors with one of the worst survival rates among all human cancers. With a more profound understanding of the cellular and molecular mechanisms of tumor initiation and acquired resistance to conventional radio- and chemotherapy, novel therapeutic targets might be discovered to optimize therapeutic approaches. In this regard, the identification of a small cellular subpopulation, called glioblastoma stem cell or stem-like cells or glioma-initiating cells or brain tumor propagating cells, has gained attention. In this article, we briefly summarize the current state of knowledge about this tumor cell population and discuss future directions for basic and clinical research.

机译：胶质母细胞瘤是高度恶性的原发性脑肿瘤，是所有人类癌症中最差的生存率之一。随着对肿瘤发生的细胞和分子机制以及对常规放射和化学疗法获得性耐药的更深刻理解，可能会发现新的治疗靶点以优化治疗方法。在这方面，识别称为胶质母细胞瘤干细胞或干样细胞或神经胶质瘤起始细胞或脑肿瘤增殖细胞的小细胞亚群已引起关注。在本文中，我们简要总结了有关该肿瘤细胞群体的知识现状，并讨论了基础和临床研究的未来方向。

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《Cell and Tissue Research》 |2011年第3期|共7页
作者
Tabatabai G; Weller M;
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正文语种 eng
中图分类细胞生物学;
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1. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. [J] . Gallia GL, Tyler BM, Hann CL, Molecular cancer therapeutics . 2009,第2期

机译：抑制Akt可抑制胶质母细胞瘤和胶质母细胞瘤干细胞的生长。
2. Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. [J] . Zhu TS, Costello MA, Talsma CE, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2011,第18期

机译：内皮细胞通过提供可促进癌症干样细胞自我更新的NOTCH配体，在胶质母细胞瘤中创建干细胞生态位。
3. A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells. [J] . Kinoshita Y, Kamitani H, Mamun MH, Neurological Research: An Interdisciplinary Quarterly Journal . 2010,第4期

机译：具有基于间充质干细胞向人胶质母细胞瘤HTB14细胞迁移的人类人工染色体载体的基因传递系统。
4. Ile-Lys-Val-Ala-Val and Leu-Arg-Glu peptide signaling in combination with matrix metalloprotease cleavable erosslinkers alter extracellular matrix degrading enzyme expression and axon extension in encapsulated human induced pluripotent stem cell derived neural stem cells. [C] . T. Hiran Perera, Laura A. Smith Callahan Society for Biomaterials annual meeting and exposition . 2019

机译：Ile-Lys-Val-Ala-Val和Leu-Arg-Glu肽信号转导与基质金属蛋白酶可切割的erosslinker结合改变封装的人诱导多能干细胞衍生的神经干细胞中细胞外基质降解酶的表达和轴突延伸。
5. Investigation of Neurochemicals' Role in Glioblastoma and Neural Stem Cells: Characterization of Dopamine Receptor D4 Inhibition in Glioblastoma Stem Cells. [D] . Dolma, Sonam. 2016

机译：研究神经化学物质在胶质母细胞瘤和神经干细胞中的作用：胶质母细胞瘤干细胞中多巴胺受体D4抑制作用的表征。
6. Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications [O] . Esperanza R. Matarredona, Angel M. Pastor 2007

机译：脑室下区的神经干细胞作为人类胶质母细胞瘤干细胞的起源。治疗意义
7. miR-30e Blocks Autophagy and Acts Synergistically with Proanthocyanidin for Inhibition of AVEN and BIRC6 to Increase Apoptosis in Glioblastoma Stem Cells and Glioblastoma SNB19 Cells. [O] . Mrinmay Chakrabarti, Daniel J Klionsky, Swapan K Ray 2016

机译：miR-30e阻断自噬和与原花青素协同作用，抑制aVEN和BIRC6，增加胶质母细胞瘤干细胞和胶质母细胞瘤sNB19细胞的凋亡。

Glioblastoma stem cells.

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