Binding ability of inpromidine, a potent H2 agonist of histamine

A. Anouar; E. Lhadi; P. DecockH. Kozlowsky

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Binding ability of inpromidine, a potent H2 agonist of histamine

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Impromidine (fig.l) is a potent and selective histamine H2 receptor agonist and its structure comprises a strongly basic guanidine group containing two different imidazole-containing side chains. The present work deals with the study of coordination equilibria between impromidine and Cu(II) and Ni(II) in aqueous solution at 25 deg C. Potentiometric, UV-Visible and EPR studies on Cu(II) complexes with impromidine have shown that this anti-ulcerogenic drug is a very potent chelating agent. This drug is found to be a very effective ligand for Ni(II) ions also. The effective coordination of impromidine to metal ions may have significant biological implications.

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《Journal de Chimie Physique et de Physico-Chimie Biologique》 |1999年第8期|1356-1366|共11页
作者
A. Anouar; E. Lhadi; P. DecockH. Kozlowsky;
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作者单位

Laboratoire de Chimie Physique Appliquess, BP, 577, Faculte des Sciences et Techniques, Settat, Maroc;

Laboratoire de l'Eau et de l'Environnement, BP. 20, Faculte des Sciences, El Jadida, Maroc;

Laboratoire d'Analyses et Chimie sous Hyperfrequences, Universite du Littoral, Dunkerque, FranceInstitute of Chemistry, University of Wroclaw, 14F. Joliot-Curie, 50-383 Wroclaw, Poland;

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正文语种英语
中图分类物理化学（理论化学）、化学物理学;
关键词
impromidine; metal complexes; stability constants; potentiometry; spectroscopy;

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机译：Cardiovascular studies with impromidine (SKF 92676), a new very potent and specific histamine H2‐receptor agonist
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Binding ability of inpromidine, a potent H2 agonist of histamine

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