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Differences in rat rbc cytosol induced after in vivo phenylhydrazine treatment.

机译:体内苯肼处理后诱导的大鼠rbc胞质溶胶的差异。

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Analysis of rat red blood cell (RBC) cytosol protein fraction after in vivo phenylhydrazine treatment revealed increased amounts of 68-kDa protein. This protein is present in trace amounts in normal rat RBC cytosol. We also present data that 68-kDa protein from RBC cytosol has an identical isoelectric point, partial proteolytic map and immunological determinants as a protein of the same molecular mass from rat exosomes. These data indicate that 68-kDa protein is normally present in rat RBC cytosol, is exported via exosomes during reticulocyte maturation, and is increased in induced haemolytic anaemia. Copyright 1999 Academic Press.
机译:体内苯肼处理后对大鼠红细胞(RBC)细胞质蛋白组分的分析显示,增加的68-kDa蛋白含量。该蛋白质在正常大鼠RBC细胞质中以痕量存在。我们还提出数据,来自RBC胞质溶胶的68 kDa蛋白具有相同的等电点,部分蛋白水解图谱和免疫学决定因子,与来自大鼠外泌体的相同分子量的蛋白相同。这些数据表明68 kDa蛋白通常存在于大鼠RBC胞质溶胶中,在网织红细胞成熟期间通过外泌体输出,并在诱导的溶血性贫血中增加。版权所有1999 Academic Press。

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