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首页> 外文期刊>Cell biology international. >The unitary evoked potential at the frog nerve-muscle junction results from synchronous gating of fusion pores at docked vesicles.
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The unitary evoked potential at the frog nerve-muscle junction results from synchronous gating of fusion pores at docked vesicles.

机译：青蛙神经-肌肉连接处的单一诱发电位是由对接囊泡上融合孔的同步门控产生的。

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Exocytosis of a single vesicle has been proposed as the mechanism which determines quantal size by releasing a prepackaged and standard amount of acetylcholine. As first described by del Castillo and Katz (1954) the endplate potential is composed of 100 unitary events and the small variance suggests a binomial release from 100 "discrete patches of membrane". However, exocytosis of 100 vesicles selected randomly from 5000 docked vesicles would yield a variance that is 7 times greater than observed values. We propose that the presynaptic ridge with its compliment of docked vesicles functions as the "discrete patch of membrane" such that arrays of calcium activated fusion pores meter transmitter to form the unit of release. A model based on the synchronous flicker of a large number of fusion pores produces the small variance of both miniature end plate potentials and unitary end plate potentials. Release from a single locus (fusion pore) would generate the sub-MEPP. This model permits vesicle trafficking and vesicular content depletion during tetanic stimulation and explains the frequency dependency of MEPP amplitudes and changes in sub-MEPP to bell-MEPP class ratios. Copyright 1999 Academic Press.
机译：已经提出单个囊泡的胞吐作用是通过释放预先包装的和标准量的乙酰胆碱来确定定量大小的机制。正如最初由del Castillo和Katz（1954）所描述的，终板电势由100个单一事件组成，并且较小的方差表明从100个“离散的膜片”中释放出二项式。但是，从5000个对接囊泡中随机选择的100个囊泡的胞吐作用会产生比观察值大7倍的方差。我们提出突触前pre及其对接的囊泡的补充起着“离散的膜片”的作用，从而使钙激活的融合孔阵列测量变送器形成的释放单元。基于大量熔合孔的同步闪烁的模型产生的微型端板电势和整体端板电势的变化很小。从单个位置（融合孔）释放会生成亚MEPP。该模型允许在强直性刺激期间囊泡运输和囊泡内容物耗竭，并解释了MEPP振幅的频率依赖性以及亚MEPP与Bell-MEPP类比的变化。版权所有1999，学术出版社。

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