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首页> 外文期刊>Cell and Tissue Research >Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.).
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Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.).

机译：幼年大菱t中胸腺的形态学和免疫组化特征（Psetta maxima，L.）。

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摘要

We performed structural and immunohistochemical studies on the thymus of juvenile turbot (Psetta maxima L.) in order to define its cellular composition. The thymic stroma was mainly composed of two subpopulations of reticulo-epithelial cells (RECs). RECs immunoreactive to anti-actin antibody were distributed through the organ, while RECs that were cytokeratin-immunopositive were located in the outer zone of the thymus. The parenchyma of the thymus was composed of several cell types such as lymphocytes/thymocytes, lymphoblasts, melano-macrophages and to a lesser extent of nurse-like cells, immunoglobulin positive (Ig+) cells, mucous cells, rodlet cells and neuroendocrine cells. CD3epsilon+ lymphocytes were mainly located in the outer zone. On the other hand, Ig+ cells were observed in the transitional region between the inner and outer zones of the thymus. The neuroendocrine cells were large and exhibited immunoreactivity to neuropeptide Y and vasoactive intestinal polypeptide. They were located in the inner zone of the thymus in close association with lymphoblasts and lymphocytes/thymocytes. This work provides useful information on the structure and cellular composition of the thymus of turbot, identifying several immunomarkers that allow the identification of different cell types, providing the basis for further studies on the immune response of turbot against diseases.
机译：我们进行了结构和免疫组化研究，对幼年大菱t（Psetta maxima L.）的胸腺进行定义。胸腺基质主要由网状上皮细胞（RECs）的两个亚群组成。对抗肌动蛋白抗体具有免疫反应性的RECs通过器官分布，而对细胞角蛋白免疫阳性的RECs位于胸腺的外部区域。胸腺的实质由几种细胞类型组成，例如淋巴细胞/胸腺细胞，淋巴母细胞，黑素巨噬细胞以及较少量的护士样细胞，免疫球蛋白阳性（Ig +）细胞，黏液细胞，小球状细胞和神经内分泌细胞。 CD3epsilon +淋巴细胞主要位于外部区域。另一方面，在胸腺的内部和外部区域之间的过渡区域中观察到Ig +细胞。神经内分泌细胞很大，并且对神经肽Y和血管活性肠多肽表现出免疫反应性。它们位于胸腺的内部区域，与淋巴母细胞和淋巴细胞/胸腺细胞紧密相关。这项工作提供了有关大菱t胸腺的结构和细胞组成的有用信息，鉴定了几种可以鉴定不同细胞类型的免疫标记，为进一步研究大菱t对疾病的免疫应答提供了基础。

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