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Tyrosine phosphorylation and synapse formation at the neuromuscular junction.

机译:在神经肌肉接头处酪氨酸磷酸化和突触形成。

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摘要

Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and synaptic plasticity. Protein tyrosine phosphorylation appears to be important in the neuron-induced synthesis of the nicotinic acetylcholine receptor and aggregation of synaptic proteins at the neuromuscular junction during development. In addition, protein tyrosine phosphorylation may regulate the ion channel activity of the nicotinic acetylcholine receptor.
机译:蛋白质酪氨酸磷酸化在整个神经系统中普遍存在。已经暗示它在神经元功能的发展和维持中起重要作用。在过去的几年中,我们对突触形成和突触可塑性的分子机制的理解取得了重大进展。蛋白酪氨酸磷酸化似乎在神经元诱导的烟碱乙酰胆碱受体的合成以及发育过程中神经肌肉接头处突触蛋白的聚集中很重要。另外,蛋白质酪氨酸磷酸化可以调节烟碱乙酰胆碱受体的离子通道活性。

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