• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Phenylpropanoid glycosides from Scrophularia scorodonia: In vitro anti-inflammatory activity
【24h】

Phenylpropanoid glycosides from Scrophularia scorodonia: In vitro anti-inflammatory activity

机译：玄参（Scrophularia scorodonia）的苯丙烷类糖苷：体外抗炎活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Five phenylpropanoid glycosides isolated from Scrophularia scorodonia L. (Scrophulariaceae), namely angoroside A (1), angoroside C (2), angoroside D (3), acteoside (4) and isoacteoside (5), had been evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These compounds have been tested in two experimental systems: ionophore-stimulated mouse peritoneal macrophages and human platelets serve as source of COX-1 and 5-LOX, and mouse peritoneal macrophages stimulated with E coli LPS are the means of testing for COX-2, NO and TNF-alpha activity. None of compounds assayed had a significant effect on LTC4-release from calcium ionophore-stimulated mouse peritoneal macrophages. However, the release of PGE(2) by mouse peritoneal macrophages stimulated with calcium ionophore was inhibited by most of these compounds. In the TXB2-release assay, acteoside (4), angoroside A (1) and angoroside C (2) showed a significant effect. These five compounds, except angoroside C (2) significantly inhibited LPS-induced PGE(2), NO and TNF-alpha in a concentration-dependent manner. In LPS-stimulated macrophages, the phenylpropanoid glycoside angoroside C (2) only had activity on NO. These results indicate that the pharmacology of these compounds may participate in the anti-inflammatory effect of Scrophularia scorodonia. (C) 2004 Elsevier Inc. All rights reserved. [References: 34]
机译：从Scrophularia scorodonia L.（Scrophulariaceae）分离得到的五种苯丙烷类糖苷，即安果糖苷A（1），安果糖苷C（2），安果糖苷D（3），Acteoside（4）和isoacteoside（5）被评估为某些抑制剂的潜在抑制剂。巨噬细胞功能参与炎症过程。这些化合物已在两个实验系统中进行了测试：离子载体刺激的小鼠腹膜巨噬细胞和人血小板充当COX-1和5-LOX的来源，而用大肠杆菌LPS刺激的小鼠腹膜巨噬细胞是测试COX-2的手段， NO和TNF-α活性。分析的化合物均未对钙离子载体刺激的小鼠腹膜巨噬细胞释放LTC4产生显着影响。但是，大多数这些化合物抑制了钙离子载体刺激的小鼠腹膜巨噬细胞释放PGE（2）。在TXB2释放试验中，洋紫苏苷（4），红果糖苷A（1）和红果糖苷C（2）表现出显着效果。这五种化合物，除Angroside C（2）以外，均以浓度依赖性方式显着抑制LPS诱导的PGE（2），NO和TNF-α。在LPS刺激的巨噬细胞中，苯丙烷类糖苷安果糖苷C（2）仅对NO具有活性。这些结果表明，这些化合物的药理作用可能参与了玄参的抗炎作用。 （C）2004 Elsevier Inc.保留所有权利。 [参考：34]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号