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首页> 外文期刊>Life sciences >Effects of Pentadecapeptide BPC157 on Regional Serotonin Synthesis in the Rat Brain: alpha-Methyl-L-Tryptophan Autoradiographic Measurements.
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Effects of Pentadecapeptide BPC157 on Regional Serotonin Synthesis in the Rat Brain: alpha-Methyl-L-Tryptophan Autoradiographic Measurements.

机译：五肽十七肽BPC157对大鼠脑区域5-羟色胺合成的影响：α-甲基-L-色氨酸放射自显影测量。

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摘要

A novel pentadecapeptide, BPC157, was recently reported to have a large spectrum of in vivo activities, from anti-ulcer to central action on the brain dopaminergic system. The mechanisms of these actions are not well understood. In this study, the evaluation of the effects of acute and repeated administration of BPC157 on serotonin (5-HT) synthesis in the rat brain is reported. The alpha-[(14)C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates. In the first series of experiments, a single dose treatment of BPC157 (10 mug/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus. 5-HT synthesis rates in the substantia nigra reticulate and medial anterior olfactory nucleus in BPC157 treated rats were significantly higher than in the control rats. No significant change in the synthesis rate was observed in the raphe nuclei. In the second series of experiments, following a 7-day treatment with BPC157 (10 mug/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive. This data suggests that BPC157, a gut peptide, influences brain 5-HT synthesis in rats, but we cannot determine, from this data, the mechanism of this action.
机译：最近报道了一种新的五肽，BPC157，具有广泛的体内活性，从抗溃疡到对脑多巴胺能系统的中枢作用。这些动作的机制尚不十分清楚。在这项研究中，报告了急性和反复给予BPC157对大鼠脑中5-羟色胺（5-HT）合成的影响的评估。 α-[[（14）C]甲基-L-色氨酸（α-MTrp）放射自显影方法用于测量区域5-HT合成速率。在第一个系列实验中，在注射α-MTrp示踪剂前40分钟腹膜内给予BPC157单剂量治疗（10杯/千克），显着降低了背丘脑，海马，外侧膝状体中5-HT合成的区域速率和下丘脑。在BPC157处理的大鼠中，黑质网状和内侧前嗅核中的5-HT合成速率显着高于对照组。在缝核中未观察到合成速率的显着变化。在第二系列实验中，在用BPC157（10 mug / kg; sc）处理7天后，在背缝核中5-HT合成速率显着降低，而在实质中则观察到显着提高。黑质，侧尾状，伏隔核和上橄榄。该数据表明，肠肽BPC157影响大鼠脑内5-HT的合成，但我们无法从该数据确定该作用机制。

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