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首页> 外文期刊>Life sciences >Autonomic neural signals in bone: Physiological implications for mandible and dental growth.
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Autonomic neural signals in bone: Physiological implications for mandible and dental growth.

机译：骨骼中的自主神经信号：下颌和牙齿生长的生理学意义。

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Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism.
机译：来自植物神经系统的信号对破骨细胞和成骨细胞功能产生有效作用。存在所有骨膜表面普遍存在的交感神经和感觉神经，其破坏影响骨重塑。在骨骼中可检测到几种神经肽，神经激素和神经递质及其受体。交感神经下颌骨中骨矿物质含量降低。当通过切下下切牙将机械应力叠加在下颌骨上时，如果交感神经完好无损，骨密度就会随之增加。观察到在受阻的萌芽侧交感神经切牙的萌发率较低，而在未受阻的一侧消融切齿的萌发率较高。正常的交感神经活动似乎是维持最小的正常无阻切牙萌发并在刺激的切牙生长条件下保持无阻发疱获得异常高速度的先决条件。这些和其他结果表明交感神经系统在下颌骨代谢中起重要作用。

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