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Influence of surgical pain stress on the blood-brain barrier permeability in rats

机译：手术疼痛应激对大鼠血脑屏障通透性的影响

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Effect of surgical pain stress on the blood-brain barrier permeability was investigated in rats. The animals were divided into four groups: Group 1: control, Group 2: immobilization stress, Group 3: acute hypertension, Group 4: immobilization stress + surgical pain stress.Bilateral hid paw surgical wounds for cannulations were applied in animals' inguinal regions under diethyl-ether anesthesia, then the animals were awaken from anesthesia to produce surgical pain stress. Evans-blue was used as a blood-brain barrier tracer. There is no significantly blood-brain barrier breakdown after short-time immobilization stress, but after adrenalin hypertension blood-brain barrier permeability was increased especially on frontal and occipital cortices in 50% of the animals. Surgical pain stress increased blood-brain barrier permeabiliy in comparison to acute adrenalin-induced hypertension (p < 0.01). In surgical pain stress-induced animals distinct Evans-blue leakage was observed in the occipital, frontal and parieto-temporal cortices. (C) 2003 Elsevier Inc. All rights reserved. [References: 27]
机译：研究了大鼠手术疼痛应激对血脑屏障通透性的影响。将动物分为四组：第一组：对照组;第二组：固定压力;第三组：急性高血压;第四组：固定压力+手术疼痛压力。然后在乙醚麻醉下将动物从麻醉中唤醒，以产生手术性疼痛压力。 Evans-blue被用作血脑屏障示踪剂。短期固定应激后没有明显的血脑屏障破坏，但在肾上腺素高血压后，尤其是在额叶和枕叶皮质中，有50％的动物血脑屏障通透性增加。与急性肾上腺素诱发的高血压相比，手术疼痛应激增加了血脑屏障通透性（p <0.01）。在手术疼痛引起的动物中，在枕骨，额叶和顶颞叶皮层中观察到明显的伊文思蓝渗漏。 （C）2003 Elsevier Inc.保留所有权利。 [参考：27]

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