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首页> 外文期刊>Life sciences >Methylnaltrexone prevents morphine-induced kaolin intake in the rat
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Methylnaltrexone prevents morphine-induced kaolin intake in the rat

机译：甲基纳曲酮可阻止吗啡诱导的大鼠高岭土摄入

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摘要

Opioids are frequently used analgesics, and emesis is a common opioid-induced adverse effect. Methylnaltrexone, a peripheral opioid antagonist, has the potential to block the undesired effects of opioids that are mediated by peripheral receptors while sparing the analgesic effect. We used a rat model of simulated emesis or pica to study if methylnaltrexone decreases morphine induced-kaolin consumption. We observed that after morphine administration, kaolin intake increased significantly compared to intake in the vehicle group, and the increase could be attenuated by ondansetron administration. Methylnaltrexone dose-dependently reduced kaolin ingestion induced by morphine. Morphine and methylnaltrexone did not significantly affect food intake and body weight in the experimental animals. Our data suggest that methylnaltrexone has therapeutic value in treating oploid-induced nausea and vomiting. (C) 2004 Elsevier Inc. All rights reserved. [References: 25]
机译：阿片类药物是常用的镇痛药，呕吐是阿片类药物引起的常见不良反应。甲基纳曲酮，一种外周类阿片拮抗剂，有可能阻止由外周受体介导的阿片类药物的不良作用，同时保留止痛作用。我们使用了模拟呕吐或异食癖的大鼠模型来研究甲基纳曲酮是否会降低吗啡诱导的高岭土消耗量。我们观察到吗啡给药后，与载体组相比，高岭土的摄入量显着增加，而昂丹司琼的给药可以减少这种增加。甲基纳曲酮剂量依赖性地减少了吗啡引起的高岭土摄入。吗啡和甲基纳曲酮对实验动物的食物摄入量和体重没有显着影响。我们的数据表明，甲基纳曲酮在治疗阿片类药物引起的恶心和呕吐方面具有治疗价值。 （C）2004 Elsevier Inc.保留所有权利。 [参考：25]

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