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首页> 外文期刊>Cell and Tissue Research >Epidermal stem cell fate: what can we learn from embryonic stem cells?
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Epidermal stem cell fate: what can we learn from embryonic stem cells?

机译：表皮干细胞命运：我们可以从胚胎干细胞中学到什么？

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摘要

Because of its constant renewal and high propensity for repair, the epidermis is, together with the gut and the hematopoietic system, a tissue of choice to explore stem cell biology. Previous research over many years has revealed the complexity of the epidermis: the heterogeneity of the stem cell compartment, with its rare, slowly cycling, multipotent, hair-follicle, "bulge" stem cells and the more restricted interfollicular, follicle-matrix, and sebaceous-gland stem cells, which in turn generate the large pool of transit-amplifying progeny. Stem cell activity has been used for some considerable time to repair skin injuries, but ex-vivo keratinocyte amplification has its limitations, and grafted skin homeostasis is not totally satisfactory. Human embryonic stem cells raise the hope that the understanding of the developmental steps leading to the generation of epidermal stem cells and the characterization of the key signaling pathways involved in skin morphogenesis (such as p63) will be translated into therapeutic benefit. Our recent results suggest the feasibility not only of identifying but also of amplifying human ES cells, early ectodermal progenitors with an intact multipotent potential that might improve the quality and functionality of grafts, provided that preclinical in vivo studies confirm our expectations from in vitro analysis.
机译：由于其不断更新和较高的修复倾向，表皮以及肠道和造血系统是探索干细胞生物学的首选组织。多年以来的先前研究揭示了表皮的复杂性：干细胞区室的异质性，具有稀有的，缓慢循环的，多能的，毛囊，“膨大”的干细胞以及更受限的卵泡间，卵泡基质和皮脂腺干细胞，继而产生大量的转运放大后代。干细胞活性已经用于修复皮肤损伤了相当长的时间，但是离体角质形成细胞的扩增有其局限性，并且移植的皮肤稳态不能完全令人满意。人类胚胎干细胞希望将对导致表皮干细胞生成的发育步骤的理解以及与皮肤形态发生有关的关键信号通路（例如p63）的表征转化为治疗益处。我们的最新结果表明，不仅可行，而且还可以扩增人ES细胞，具有完整多能潜能的早期外胚层祖细胞，这可能会改善移植物的质量和功能，但前提是临床前体内研究证实了我们对体外分析的期望。

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