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首页> 外文期刊>Cell and Tissue Research >Identification of very small embryonic like (VSEL) stem cells in bone marrow.
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Identification of very small embryonic like (VSEL) stem cells in bone marrow.

机译：鉴定骨髓中非常小的胚胎样（VSEL）干细胞。

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Bone marrow (BM) develops in mammals by the end of the second/beginning of the third trimester of gestation and becomes a major hematopoietic organ in postnatal life. The alpha-chemokine stromal derived factor-1 (SDF-1) to CXCR4 ([Formula: see text]-protein-coupled seven transmembrane-spanning chemokine receptor) axis plays a major role in BM colonization by stem cells. By the end of the second trimester of gestation, BM becomes colonized by hematopoietic stem cells (HSC), which are chemoattracted from the fetal liver in a CXCR4-SDF-1-dependent manner. Whereas CXCR4 is expressed on HSC, SDF-1 is secreted by BM stroma and osteoblasts that line BM cavities. Mounting evidence indicates that BM also contains rare CXCR4(+) pluripotent stem cells (PSC). Recently, our group has identified a population of CXCR4(+) very small embryonic like stem cells in murine BM and human cord blood. We hypothesize that these cells are deposited during development in BM as a mobile pool of circulating PSC that play a pivotal role in postnatal tissue turnover, both of non-hematopoietic and hematopoietic tissues.
机译：骨髓（BM）会在妊娠的中期或中期开始发育，并成为产后生活中的主要造血器官。 CXCR4（化学式为蛋白偶联的七个跨膜趋化因子受体）轴的α趋化因子基质衍生因子-1（SDF-1）轴在干细胞对BM的定殖中起主要作用。到妊娠中期，BM会被造血干细胞（HSC）定植，造血干细胞以依赖CXCR4-SDF-1的方式从胎儿肝脏中被化学吸引。 CXCR4在HSC上表达，而SDF-1是由BM基质和衬在BM腔中的成骨细胞分泌的。越来越多的证据表明，BM还含有稀有的CXCR4（+）多能干细胞（PSC）。最近，我们的研究小组在鼠BM和人脐带血中鉴定出一群CXCR4（+）非常小的胚胎样干细胞。我们假设这些细胞在发育过程中作为循环的PSC的移动池在BM中沉积，在非造血和造血组织的产后组织更新中起着关键作用。

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