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首页> 外文期刊>Life sciences >Exposure to stress differential vascular adaptive response in spontaneously hypertensive and Wistar rats: Role of nitric oxide, and prehypertensive and hypertensive states.
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Exposure to stress differential vascular adaptive response in spontaneously hypertensive and Wistar rats: Role of nitric oxide, and prehypertensive and hypertensive states.

机译：自发性高血压和Wistar大鼠应激差异性血管适应性反应的暴露：一氧化氮的作用以及高血压和高血压状态。

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Stress-induced vascular adaptive response in SHR was investigated, focusing on the endothelium. Noradrenaline responses were studied in intact and denuded aortas from 6-week-old (prehypertensive) and 14-week-old (hypertensive) SHR and age-matched Wistar rats submitted or not to acute stress (20-min swimming and 1-h immobilization 25 min apart), preceded or not by chronic stress (2 sessions 2 days apart of 1-h day immobilization for 5-consecutive days). Stress did not alter the reactivity of denuded aorta. Moreover, no alteration in the EC50 values was observed after stress exposure. In intact aortas, acute stress-induced hyporeactivity to noradrenaline similar between strains at both age. Chronic stress potentiated this adaptive response in 6- and 14-week-old Wistar but not in 6-week-old SHR, and did not alter the reactivity of 14-week-old SHR. Maximum response (g) in intact aortas [6-week-old: Wistar 3.25+/-0.12, Wistar/acute 1.95+/-0.12*, Wistar/chronic 1.36+/-0.21*(+), SHR 1.75+/-0.11, SHR/acute 0.88+/-0.08*, SHR/chronic 0.85+/-0.05*; 14-week-old: Wistar 3.83+/-0.13, Wistar/acute 2.72+/-0.13*, Wistar/chronic 1.91+/-0.19*(+), SHR 4.03+/-0.17, SHR/acute 2.26+/-0.12*, SHR/chronic 4.10+/-0.23; inside the same strain: *P < 0.05 relate to non-stressed rat, +P < 0.05 related to acute stressed rat; n = 6-18]. Independent of age and strain, L-NAME and endothelium removal abolished the stress-induced aorta hyporeactivity. CONCLUSION: The vascular adaptive response to stress is impaired in SHR, independently of the hypertensive state. Moreover, this vascular adaptive response is characterized by endothelial nitric oxide-system hyperactivity in both strains.
机译：研究了SHR中应激诱导的血管适应性反应，重点是内皮。在6周龄（高血压前）和14周龄（高血压）SHR和年龄相匹配的Wistar大鼠中，对未受过急性应激（20分钟游泳和1小时固定）的去甲肾上腺素反应进行了研究间隔25分钟），先于还是不伴有慢性压力（固定2小时，每隔1小时固定2天，连续5天）。压力没有改变裸主动脉的反应性。此外，应力暴露后未观察到EC50值的变化。在完整的主动脉中，急性应激引起的去甲肾上腺素反应性低下在两个年龄段的菌株之间相似。慢性应激会在6周和14周龄的Wistar中增强这种适应性反应，而在6周龄的SHR中则没有，并且不会改变14周龄SHR的反应性。完整主动脉的最大反应（g）[6周龄：Wistar 3.25 +/- 0.12，Wistar /急性1.95 +/- 0.12 *，Wistar /慢性1.36 +/- 0.21 *（+），SHR 1.75 +/- 0.11，SHR /急性0.88 +/- 0.08 *，SHR /慢性0.85 +/- 0.05 *; 14周龄：Wistar 3.83 +/- 0.13，Wistar /急性2.72 +/- 0.13 *，Wistar /慢性1.91 +/- 0.19 *（+），SHR 4.03 +/- 0.17，SHR /急性2.26 +/- 0.12 *，SHR /慢性4.10 +/- 0.23;在同一品系内：* P <0.05与非应激大鼠有关，+ P <0.05与急性应激大鼠有关; n = 6-18]。不受年龄和劳损的影响，L-NAME和内皮细胞去除消除了应激诱导的主动脉反应性降低。结论：与高血压状态无关，SHR损害了血管对压力的适应性反应。此外，该血管适应性反应的特征在于两种菌株中的内皮一氧化氮系统过度活跃。

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