• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Effect of social isolation on 24-h pattern of stress hormones and leptin in rats
【24h】

Effect of social isolation on 24-h pattern of stress hormones and leptin in rats

机译：社会隔离对大鼠应激激素和瘦素24小时模式的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This work analyzes the effect of social isolation of growing male rats on 24-h changes of plasma prolactin, growth hormone, ACTH and leptin, and on plasma and adrenal corticosterone concentrations. At 35 days of life, rats were either individually caged or kept in groups (6-8 animals per cage) under a 12:12 h light/dark schedule (lights on at 08:00 h). A significant arrest of body weight gain regardless of unchanged daily food intake was found in isolated rats after 2 weeks of isolation. On the 4th week, rats were killed at 6 time intervals during a 24-h cycle, beginning at 09:00 It. In isolated rats the 24-h pattern of all parameters tested became distorted, as assessed by Cosinor analysis. When analyzed as a main factor in a factorial analysis of variance, isolation decreased plasma prolactin and growth honnone, increased plasma leptin and corticosterone while decreased adrenal corticosterone. Plasma corticosterone levels correlated significantly with plasma ACTH and with adrenal corticosterone levels in group-caged rats only. These changes can be attributed to an effect of mild stress on the endogenous clock that modulates the circadian hormone release. (c) 2005 Elsevier Inc. All rights reserved.
机译：这项工作分析了成年雄性大鼠的社会隔离对血浆催乳素，生长激素，ACTH和瘦素的24小时变化以及血浆和肾上腺皮质激素浓度的影响。在35天的生命中，将大鼠单独关在笼中或分组饲养（每笼6-8只动物），光照/黑暗时间表为12:12 h（在08:00 h点亮）。隔离2周后，在隔离大鼠中，无论每日食物摄入量如何，体重增加都明显停止。在第4周，从09:00开始在24小时周期内以6个时间间隔杀死大鼠。通过Cosinor分析评估，在离体大鼠中，所有测试参数的24小时模式变得失真。当作为方差分析的主要因素进行分析时，隔离可降低血浆催乳激素和生长激素的含量，增加血浆瘦素和皮质酮的含量，同时降低肾上腺皮质酮的含量。仅在成笼笼养的大鼠中，血浆皮质类固醇水平与血浆ACTH和肾上腺皮质类固醇水平显着相关。这些变化可以归因于对内源性时钟的轻度压力的影响，所述内源性时钟调节昼夜节律激素的释放。 （c）2005 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号