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Association between glutamine extraction and release of citrulline and glycine by the human small intestine

机译：谷氨酰胺提取与人小肠释放瓜氨酸和甘氨酸的关系

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Although glutamine is an important fuel for the intestinal epithelium, the metabolic fate of glutamine extracted by the human intestine remains unclear. The aim of this study was to investigate the relationship between glutamine extraction and the release of other amino acids by the human intestine. In 21 patients undergoing major abdominal cancer surgery, differences in the plasma concentrations of 22 amino acids including glutamine across the superior or inferior mesenteric vein draining viscera were measured using a high-performance liquid chromatography. Arterial minus venous (A - V) or venous minus arterial (V-A) balances of the amino acids were calculated, and then the correlations between A-V differences of glutamine and V-A differences of amino acids released from the intestine were analyzed. Mean extraction rate of glutamine by the small intestine was 28.45%, approximately 3 times higher than 9.41% in the distal colon. Citrulline, proline, alanine, glycine, and arginine were released by the small intestine into the portal circulation. Positive correlations were found between glutamine uptake and the production of citrulline (r=0.814, P=0.0013) and glycine (r=0.734, P=0.0080). In conclusion, the synthesis of citrulline from glutamine by the small intestine is highly suspected, and the contribution of gut glutamine extraction to the release of glycine into the portal circulation is also supposed. (C) 2007 Elsevier Inc. All rights reserved.
机译：尽管谷氨酰胺是肠上皮的重要燃料，但人体肠道提取的谷氨酰胺的代谢命运仍不清楚。这项研究的目的是研究谷氨酰胺提取与人体肠道其他氨基酸的释放之间的关系。在21例接受重大腹部癌手术的患者中，使用高效液相色谱法测量了肠系膜上，下肠系膜静脉引流内脏和下肠内的22种氨基酸（包括谷氨酰胺）的血浆浓度差异。计算氨基酸的动静脉（AV）或动静脉（V-A）平衡，然后分析谷氨酰胺的A-V差异与从肠道释放的氨基酸的V-A差异之间的相关性。小肠对谷氨酰胺的平均提取率为28.45％，约为远端结肠中9.41％的3倍。瓜氨酸，脯氨酸，丙氨酸，甘氨酸和精氨酸被小肠释放到门脉循环中。发现谷氨酰胺摄入量与瓜氨酸产量（r = 0.814，P = 0.0013）和甘氨酸（r = 0.734，P = 0.0080）之间呈正相关。总之，高度怀疑小肠由谷氨酰胺合成瓜氨酸，还推测了谷氨酰胺提取物对甘氨酸释放到门脉循环中的作用。 （C）2007 Elsevier Inc.保留所有权利。

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