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首页> 外文期刊>Life sciences >S-allylcysteine ameliorates isoproterenol-induced cardiac toxicity in rats by stabilizing cardiac mitochondrial and lysosomal enzymes.
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S-allylcysteine ameliorates isoproterenol-induced cardiac toxicity in rats by stabilizing cardiac mitochondrial and lysosomal enzymes.

机译：S-烯丙基半胱氨酸可通过稳定心脏线粒体和溶酶体酶来改善异丙肾上腺素引起的大鼠心脏毒性。

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摘要

This study was aimed to evaluate the preventive role of S-allylcysteine (SAC) on mitochondrial and lysosomal enzymes in isoproterenol (ISO)-induced rats. Male albino Wistar rats were pretreated with SAC (50, 100 and 150 mg/kg) daily for a period of 45 days. After the treatment period, ISO (150 mg/kg) was subcutaneously injected to rats at an interval of 24 h for two days. The activities of heart mitochondrial enzymes (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase and alpha-ketoglutarate dehydrogenase) and respiratory chain enzymes (NADH dehydrogenase and cytochrome C oxidase) were decreased significantly (p<0.05) in ISO-induced rats. The activities of lysosomal enzymes (beta-glucuronidase, beta-N-acetyl glucosaminidase, beta-galactosidase, cathepsin-D and acid phosphatase) were increased significantly (p<0.05) in serum and heart of ISO-induced rats. Pretreatment with SAC (100 mg/kg and 150 mg/kg) for a period of 45 days increased significantly (p<0.05) the activities of mitochondrial and respiratory chain enzymes and decreased the activities of lysosomal enzymes significantly (p<0.05) in ISO-induced rats. Oral administration of SAC (50, 100 and 150 mg/kg) for a period of 45 days to normal rats did not show any significant (p<0.05) effect in all the parameters studied. The altered electrocardiogram (ECG) of ISO-treated rats was also restored to near normal by treatment with SAC (100 and 150 mg/kg). These results confirm the efficacy of SAC in alleviating ISO-induced cardiac damage.
机译：这项研究旨在评估S-烯丙基半胱氨酸（SAC）对异丙肾上腺素（ISO）诱导的大鼠线粒体和溶酶体酶的预防作用。每天用SAC（50、100和150 mg / kg）预处理雄性白化Wistar大鼠45天。在治疗期之后，以24小时的间隔皮下向大鼠皮下注射ISO（150mg / kg），持续两天。在ISO诱导的大鼠中，心脏线粒体酶（异柠檬酸脱氢酶，琥珀酸脱氢酶，苹果酸脱氢酶和α-酮戊二酸脱氢酶）和呼吸链酶（NADH脱氢酶和细胞色素C氧化酶）的活性显着降低（p <0.05）。在ISO诱导的大鼠血清和心脏中，溶酶体酶（β-葡萄糖醛酸苷酶，β-N-乙酰氨基葡萄糖苷酶，β-半乳糖苷酶，组织蛋白酶D和酸性磷酸酶）的活性显着增加（p <0.05）。在ISO中用SAC（100 mg / kg和150 mg / kg）预处理45天显着增加（p <0.05）线粒体和呼吸链酶的活性，并降低溶酶体酶的活性（p <0.05）诱导的大鼠。对正常大鼠口服SAC（50、100和150 mg / kg）持续45天，在所有研究的参数中均未显示任何显着（p <0.05）效果。通过用SAC（100和150 mg / kg）治疗，经ISO治疗的大鼠的改变后的心电图（ECG）也恢复至接近正常。这些结果证实了SAC在减轻ISO引起的心脏损害中的功效。

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