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首页> 外文期刊>Life sciences >The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats.
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The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats.

机译：ghrelin集中给药对大鼠垂体ACTH细胞和循环ACTH和皮质酮的影响。

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Ghrelin is a brain-gut peptide known for its growth hormone (GH)-releasing and appetite-inducing activities. This natural GH secretagogue (GHS) was originally purified from rat stomach, but it is expressed widely in different tissues where it may have endocrine and paracrine effects. The central effects of ghrelin on adrenocorticotropic hormone (ACTH) cells, ACTH release and subsequent corticosterone release from adrenal glands remains to be clarified. The aim of this study was to specifically determine the morphological features of ACTH-producing pituicytes and blood concentration of ACTH and corticosterone after central administration of ghrelin. Five doses of rat ghrelin or PBS (n=10 per group) were injected every 24 h (1 microg of ghrelin in 5 muL PBS), into the lateral cerebral ventricle of male rats. Results showed that ghrelin increased (p<0.05) absolute and relative pituitary weights compared to controls (58% and 41% respectively). Morphometric parameters, i.e. the volume of the ACTH cells, nuclear volume, and volume density were all increased (p<0.05), by 17%, 6% and 13%, respectively, 2 h after the last ghrelin treatment. Ghrelin increased circulating concentrations of ACTH and corticosterone (p<0.05) by 62% and 66%, respectively. The data provide clear documentation that intracerebroventricular ghrelin stimulates ACTH cell hypertrophy and proliferation, and promotes ACTH and corticosterone release. Determining the role of ghrelin in physiological stress responses and whether control of the peptide's activity would be useful for prevention and/or treatment of stress-induced diseases remain important research goals.
机译：Ghrelin是一种脑肠肽，以其释放生长激素（GH）和诱导食欲的活性而闻名。这种天然的GH促分泌素（GHS）最初是从大鼠的胃中提纯的，但在不同的组织中广泛表达，可能具有内分泌和旁分泌作用。 ghrelin对肾上腺促肾上腺皮质激素（ACTH）细胞，ACTH释放以及随后皮质酮从肾上腺释放的中心作用仍有待阐明。这项研究的目的是具体确定生长激素释放肽后产生ACTH的皮细胞的形态特征以及ACTH和皮质酮的血药浓度。每24小时注射五剂大鼠生长激素释放肽或PBS（每组n = 10）（在5μLPBS中加入1微克生长素释放肽）到雄性大鼠的侧脑室。结果表明，与对照组相比，ghrelin的垂体绝对和相对体重增加了（p <0.05）（分别为58％和41％）。在最后的生长素释放肽处理后2小时，形态学参数，即ACTH细胞的体积，核体积和体积密度均分别增加了（p ＜0.05）17％，6％和13％。 Ghrelin使ACTH和皮质酮的循环浓度分别增加62％和66％（p <0.05）。数据提供了明确的证据，表明脑室内生长素释放肽刺激ACTH细胞肥大和增殖，并促进ACTH和皮质酮释放。确定生长激素释放肽在生理应激反应中的作用以及控制该肽的活性是否对预防和/或治疗应激诱导的疾病有用仍然是重要的研究目标。

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