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首页> 外文期刊>Life sciences >THYROIDECTOMY DOES NOT ALTER HYPOTHALAMIC OXYTOCIN AND VASOPRESSIN EXPRESSION IN CHRONICALLY HYPERNATREMIC RATS
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THYROIDECTOMY DOES NOT ALTER HYPOTHALAMIC OXYTOCIN AND VASOPRESSIN EXPRESSION IN CHRONICALLY HYPERNATREMIC RATS

机译：甲状腺功能减退症不会改变慢性高蛋白血症大鼠的下丘脑催产素和血管加压素的表达

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Sustained hyperosmolality increases the levels of hypothalamic oxytocin (OT) and arginine vasopressin (AVP) messenger ribonucleic acids (mRNAs). Gonadectomy is known to abolish this response (12,18). In this study we investigated whether thyroidectomy would alter OT and AVP mRNA levels in the hypothalamic paraventricular nucleus (PVN) of the hyperosmotically stimulated rat. Male Sprague-Dawley rats underwent thyroidectomy (hypothyroid) or sham thyroidectomy (euthyroid) at 7 weeks of age. Three weeks later hypothyroid and euthyroid animals were administered 2% NaCl (6-11 days) or tap water and sacrificed at the end of the experiment. Northern blot hybridization was used to assess size and levels of hypothalamic OT and AVP mRNAs. Hypothyroid rats had significantly lower levels of serum thyroxine (T-4) than their euthyroid cohorts (P < 0.0001). Both the euthyroid and the hypothyroid animals receiving 2% NaCl developed hypernatremia and increased the levels and the size of OT and AVP mRNAs compared to their tap water cohorts. We conclude that in contrast to gonadectomy, thyroidectomy does not alter the level of OT and AVP mRNAs in the hypothalamus of chronically hypernatremic male rats. [References: 24]
机译：持续的高渗透压会增加下丘脑催产素（OT）和精氨酸加压素（AVP）信使核糖核酸（mRNA）的水平。已知性腺切除术可以消除这种反应（12,18）。在这项研究中，我们调查了甲状腺切除术是否会改变高渗刺激大鼠的下丘脑室旁核（PVN）中的OT和AVP mRNA水平。雄性Sprague-Dawley大鼠在7周龄时接受了甲状腺切除术（甲状腺功能减退）或假甲状腺切除术（甲状腺功能正常）。三周后，给甲状腺功能减退和甲状腺功能正常的动物施用2％NaCl（6-11天）或自来水，并在实验结束时处死。 Northern印迹杂交用于评估下丘脑OT和AVP mRNA的大小和水平。甲状腺功能减退的大鼠的血清甲状腺素（T-4）水平明显低于正常甲状腺的人群（P <0.0001）。与自来水队列相比，接受2％NaCl的正常甲状腺和甲状腺功能减退的动物均会发生高钠血症，并增加OT和AVP mRNA的水平和大小。我们得出的结论是，与性腺切除术相反，甲状腺切除术不会改变慢性高钠血症雄性大鼠下丘脑中OT和AVP mRNA的水平。 [参考：24]

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