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REDUCTION OF BILE SECRETION BY PROSTAGLANDINS IN THE RAT IN VIVO

机译：体内前列腺素减少胆汁分泌

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Bile secretion has been reported to be regulated by circulating hormones and by autonomic liver nerves. In the in situ perfused rat liver, prostaglandins reduce bile flow and bile acid secretion. The aim of this study was to investigate the regulation of bile secretion by prostaglandins in the in vivo situation. The bile duct and portal vein of anaesthetised Wistar rats were cannulated by polyethylene tubes. Bile flow was determined gravimetrically. Bile acids were quantified by the 3-alpha-hydroxysteroid-dehydrogenase method and by high-pressure-liquid-chromatography (HPLC) separation. Administration of 1 mu M prostaglandin F-2 alpha into the portal vein over 5 minutes reduced bile flow from 1.57 mu l/min . g liver to 0.95 mu l/min . g liver and bile acids secretion from 148 to 81 nmol/100g/min. The administration of different doses (0.1 mu M, 1 mu M, 10 mu M) of prostaglandin F-2 alpha reduced hepatic bile secretion in a dose-dependent manner. Similar effects were observed after infusion of prostaglandin D-2. However, the ratio of the bile acids (alpha-tauromuricholic acid, beta-tauromuricholic acid, taurocholic acid, taurochenodeoxycholic acid, and taurodeoxycholic acid) was unchanged by prostaglandin F-2 alpha. In conclusion, infusion of prostaglandin F-2 alpha into the portal vein results in a reduction of bile flow and bile acid secretion in a dose-dependent manner. These results suggest that the effect is linked to canicular bile secretion. [References: 28]
机译：据报道胆汁分泌受循环激素和自主神经的调节。在原位灌注的大鼠肝脏中，前列腺素会减少胆汁流量和胆汁酸分泌。这项研究的目的是研究在体内情况下前列腺素对胆汁分泌的调节。用聚乙烯管插管麻醉的Wistar大鼠的胆管和门静脉。胆汁流由重量法确定。胆汁酸通过3-α-羟基类固醇脱氢酶方法和高压液相色谱（HPLC）分离进行定量。在5分钟内向门静脉内注射1μM前列腺素F-2 alpha可使胆汁流量从1.57μl/ min减少。 g肝至0.95μl/ min。 g肝和胆汁酸的分泌从148至81 nmol / 100g / min。施用不同剂量（0.1μM，1μM，10μM）的前列腺素F-2α以剂量依赖的方式减少了肝胆汁的分泌。输注前列腺素D-2后观察到类似的效果。但是，前列腺素F-2α的胆汁酸（α-牛磺尿酸，β-牛磺胆酸，牛磺胆酸，牛磺去氧胆酸和牛磺脱氧胆酸的比例）没有变化。总之，向门静脉输注前列腺素F-2α导致胆汁流量减少和胆汁酸分泌呈剂量依赖性。这些结果表明该作用与小管胆汁分泌有关。 [参考：28]

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