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首页> 外文期刊>Life sciences >THE EFFECT OF TILSUPROST ON THE LIVER MITOCHONDRIA IN TAUROCHOLATE PANCREATITIS IN RATS WITH ANTECEDENT ACUTE ETHANOL ABUSE
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THE EFFECT OF TILSUPROST ON THE LIVER MITOCHONDRIA IN TAUROCHOLATE PANCREATITIS IN RATS WITH ANTECEDENT ACUTE ETHANOL ABUSE

机译：替洛舒斯特对急性酒精滥用大鼠胆胰胰腺肝线粒体的影响。

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摘要

The damage to the liver appears to be an important aspect of multisystem organ failure in acute pancreatitis with poor prognosis. The objective of this study was to evaluate the protective effect of stable prostacyclin analogue - tilsuprost on the liver energy metabolism in taurocholate pancreatitis in rats preceded by acute ethanol intake. The respiratory control ratio (RCR) and ADP/O ratio of liver mitochondria with glutamate + malate as substrates and mitochondrial DNP (uncoupler) - dependent ATPase activity were significantly depressed after 12 h of taurocholate pancreatitis - the effects that were not significantly aggravated by antecedent acute etanol intake. Tilsuprost (0.3 mg/kg i.g.) given just before induction of pancreatitis partly prevented the impairment of mitochondrial oxidative and phosphorylative functions, however these positive effects were limited in acute pancreatitis preceded by acute ethanol intake. These results suggest that prostacyclin analogues could be effective in the treatment of hepatic complications in acute pancreatitis, however their effectiveness could be limited in the case of acute ethanol antecedent abuse. [References: 33]
机译：肝损害似乎是预后不良的急性胰腺炎多系统器官衰竭的重要方面。这项研究的目的是评估稳定的前列环素类似物-替洛舒前列素对牛磺酸胆碱性胰腺炎大鼠急性摄入乙醇后肝脏能量代谢的保护作用。牛磺酸胆囊性胰腺炎后12 h，以谷氨酸+苹果酸为底物的肝线粒体的呼吸控制率（RCR）和ADP / O比值以及线粒体DNP（解偶联剂）依赖性ATPase活性显着降低-先前的作用并未明显加剧这种影响急性乙醇摄入。在诱导胰腺炎之前给予Tilsuprost（0.3 mg / kg i.g.）可以部分预防线粒体氧化和磷酸化功能的损害，但是这些积极作用在急性乙醇摄入前急性胰腺炎中受到限制。这些结果表明，前列环素类似物可以有效治疗急性胰腺炎的肝并发症，但是在急性乙醇前期滥用的情况下，其有效性可能受到限制。 [参考：33]

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