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首页> 外文期刊>Life sciences >INVOLVEMENT OF SOMATOSTATIN, BOMBESIN AND SEROTONIN IN THE ORIGIN OF THE MIGRATING MYOELECTRIC COMPLEX IN SHEEP
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INVOLVEMENT OF SOMATOSTATIN, BOMBESIN AND SEROTONIN IN THE ORIGIN OF THE MIGRATING MYOELECTRIC COMPLEX IN SHEEP

机译：绵羊迁移性肌络合物起源中生长抑素，血脂和血清素的参与

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Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/min) or serotonin (5-HT, 4 mu g/kg/min) for 5 min, induced a duodenal myoelectric activity front followed by a period of quiescence. These duodenal events were concomitant with an antral inhibition. This pattern resembled that observed in a spontaneous migrating myoelectric complex (MMC) in sheep. Bombesin and 5-HT evoked an additional and transient increase in antral activity simultaneously with the duodenal activity front. On the other hand, plasma i.r. motilin levels did not show any fluctuations during spontaneous MMC cycles or after somatostatin, bombesin or 5-HT infusions. Likewise, plasma i.r. bombesin levels remained unchanged during spontaneous MMC or after administration of somatostatin. However, 5-HT-induced duodenal activity fronts were closely associated with a sharp peak in plasma i.r. bombesin. Finally, plasma i.r. somatostatin concentrations rose at the end of spontaneous phase III and peaked in phase I. A similar pattern of somatostatin release in plasma was found while the duodenal activity front and quiescence period developed after either 5-HT or bombesin infusions. These results do not indicate a role for motilin in the control of MMCs in sheep, although a definitive conclusion cannot be drawn until synthetic sheep motilin is available. However, our data suggest that somatostatin and bombesin-like peptides as well as 5-HT, acting in a coordinated manner, could be involved in the regulation of cyclical antroduodenal motor events in sheep. [References: 51]
机译：长期植入肌壁的电极在有意识的绵羊中记录了十二指肠肌电活动。此外，通过RIA测定血浆免疫反应性（i.r.）胃动素，生长抑素和蛙皮素的浓度。静脉注射生长抑素（20 ng / kg / min），蛙皮素（10 ng / kg / min）或血清素（5-HT，4μg/ kg / min）5分钟，诱导十二指肠肌电活动前沿，随后静止期。这些十二指肠事件伴有肛门抑制。这种模式类似于在绵羊中自发迁移的肌电复合体（MMC）中观察到的模式。 Bombesin和5-HT引起十二指肠活动前沿同时并短暂地增加了肛门活动。另一方面，等离子胃动素水平在自发的MMC周期中或生长抑素，蛙皮素或5-HT输注后未显示任何波动。同样，等离子自发性MMC期间或服用生长抑素后，血红素水平保持不变。但是，5-HT诱导的十二指肠活动前沿与血浆I.r.轰炸蛋白。最后，等离子生长抑素浓度在自发的III期末期上升，并在I期达到峰值。在5-HT或蛙皮素输注后，十二指肠活性前沿和静止期出现，血浆中生长抑素的释放模式相似。这些结果并不表明胃动蛋白在控制绵羊MMC中具有一定的作用，尽管直到有合成的绵羊胃动蛋白可用时才能得出明确的结论。但是，我们的数据表明，生长抑素和蛙皮素样肽以及5-HT以协调的方式起作用，可能参与了绵羊周期性十二指肠运动事件的调节。 [参考：51]

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