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Translation in the mammalian oocyte in space and time

机译:在哺乳动物卵母细胞中的时空翻译

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摘要

A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Posttranscriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
机译:哺乳动物卵母细胞发育的标志是依赖于所存储的RNA和蛋白质的翻译和利用,而不是基因的从头转录,以维持减数分裂进程和早期胚胎发育。在没有转录的情况下,哺乳动物减数分裂的完成和早期胚胎的发育极大地依赖于母体合成的RNA。在翻译水平上基因表达的转录后控制已成为正常发育中的重要细胞功能。因此,卵母细胞中基因表达的调节几乎仅在mRNA,蛋白质稳定化和蛋白质合成水平上受到控制。当前的审查集中在最近出现的关于与哺乳动物卵母细胞减数分裂进程的时间和空间翻译控制有关的RNA分布的发现。

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