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Estrogen modulates the action of nitric oxide in the medial preoptic area on luteinizing hormone and prolactin secretion

机译：雌激素调节视前内侧一氧化氮对促黄体激素和催乳激素分泌的作用

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摘要

Several substances work as neuromediators of the estrogen direct and indirect (throught glial cells or interneurons) action on luteinizing hormone- releasing hormone (LH-RH) neurons in medial basal hypothalamus and medial preoptic area (MPOA).Angiotensin II (AII) in the MPOA stimulates the LH and it inhibits PRL secretion in some situations. On the other hand, the effect of excitatory aminoacids on LH and PRL surges during proestrus as well LH surge induced by steroids depend on nitric oxide (NO). In the present study we investigated the participation of MPOA endogenous NO on gonadotropin and PRL secretion mediated by estrogen and AII. Plasma LH, FSH and PRL was determinated in estrogen primed and unprimed ovariectomized Wistar rats that received microinjection of AII or saline into the MPOA, associated or not with a previous microinjection of an inhibitor for NOS. Our results show the following: 1- there was no change in plasma FSH in estrogen- primed or umprimed ovarictomized related with microinjections of All or NO antagonist in the MPOA; 2- the increase in LH secretion after ovariectomy depends on, at least in part, NO activity in the MPOA; 3- estrogen may have an indirect negative feedback action on LH-RH neurons in the MPOA through NO; 4- the stimulatory action of AII in the MPOA on LH secretion in ovariectomized rats treated with estrogen depends on NO; 5- NO in the MPOA stimulates or inhibits PRL secretion depending on the absence or presence of estrogen, respectively; 6- the inhibitory action of AII into the MPOA on PRL secretion does not seem to depend on NO. (C) 2003 Elsevier Inc. All rights reserved. [References: 47]
机译：几种物质可作为雌激素直接和间接（通过神经胶质细胞或中间神经元）直接或间接作用于内侧基底下丘脑和内侧视前区（MPOA）的促黄体激素释放激素（LH-RH）神经元的神经介质。 MPOA在某些情况下会刺激LH并抑制PRL分泌。另一方面，兴奋性氨基酸对发情期LH和PRL激增以及类固醇诱导的LH激增的影响取决于一氧化氮（NO）。在本研究中，我们调查了MPOA内源性NO对雌激素和AII介导的促性腺激素和PRL分泌的参与。在雌激素引发和未引发卵巢切除的Wistar大鼠中测定血浆LH，FSH和PRL，该大鼠接受MPII微量注射AII或生理盐水，与先前微量注射NOS抑制剂有关或无关。我们的结果显示以下内容：1-在MPOA中微量注射All或NO拮抗剂后，雌激素启动或未启动的卵巢切除术中血浆FSH没有变化; 2-卵巢切除术后LH分泌的增加至少部分取决于MPOA中的NO活性; 3-雌激素可能通过NO对MPOA中的LH-RH神经元具有间接的负反馈作用; 4-MPII中的AII对用雌激素处理的去卵巢的大鼠的LH分泌的刺激作用取决于NO; MPOA中的5- NO分别根据是否存在雌激素刺激或抑制PRL分泌; 6-AII进入MPOA对PRL分泌的抑制作用似乎不依赖于NO。 （C）2003 Elsevier Inc.保留所有权利。 [参考：47]

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