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Neurosteroids and neuroactive drugs in mental disorders.

机译：精神障碍中的类固醇和神经活性药物。

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Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathological conditions characterized by emotional or affective disturbances, including major depression, anxiety disorders, and schizophrenia. Moreover, it has been shown that administration of drugs having clinical relevance in the treatment of these pathologies influence the secretion of these steroids. It remains to be determined, however, whether such changes in the concentrations of neuroactive steroids are a cause of, a risk factor for, or a consequence of mental disorders. The observation that effective pharmacological treatment of some of these pathologies influences the concentrations of neuroactive steroids suggests that these endogenous compounds might themselves prove to be efficacious in the treatment of mental illness.
机译：临床和临床前研究表明，孕酮和脱氧皮质酮及其代谢产物3α，5α-四氢孕酮和3α，5α-四氢脱氧皮质酮的外周和脑中浓度的波动可能分别在某些以情绪或情感障碍为特征的病理状况中起重要作用。包括重度抑郁症，焦虑症和精神分裂症。此外，已经显示在这些病理学的治疗中具有临床意义的药物的施用影响这些类固醇的分泌。但是，神经活性类固醇浓度的这种变化是否是精神障碍的原因，危险因素或结果尚待确定。对这些病理中的某些进行有效药理治疗会影响神经活性类固醇浓度的观察结果表明，这些内源性化合物本身可能被证明对治疗精神疾病有效。

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