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Pycnogenol (R), French maritime pine bark extract, improves endothelial function of hypertensive patients

机译：碧萝ogen（R），法国海上松树皮提取物，可改善高血压患者的内皮功能

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摘要

A placebo-controlled, double-blind, parallel group study was performed with 58 patients to investigate effects of French maritime pine bark extract, Pycnogenol(R), on patients with hypertension. Supplementation of the patients with 100 mg Pycnogenol(R) over a period of 12 weeks helped to reduce the dose of the calcium antagonist nifedipine in a statistically significant manner. The intake of Pycnogenol(R) decreased endothelin-1 concentrations significantly compared to placebo while concentrations of 6-keto prostaglandin F1a in plasma were significantly higher compared to placebo. Values for nitric oxide (NO) in plasma increased in both groups, but the differences were not significant. Angiotensin II concentrations in plasma were lowered in the placebo group to a larger extent than in the Pycnogenol(R) group. Heart rate, electrolytes and blood urea nitrogen were not changed during treatment in both groups of patients. Unwanted effects observed in both groups were of mild and transient nature, such as gastrointestinal problems, vertigo, headache and nausea. Differences in rate of side effects were not statistically significant between the two groups. Study results support a supplementation with Pycnogenol(R) for mildly hypertensive patients. (C) 2003 Elsevier Inc. All rights reserved. [References: 9]
机译：对58例患者进行了安慰剂对照，双盲，平行分组研究，以研究法国海洋松树皮提取物Pycnogenol（R）对高血压患者的影响。在12周内向患者补充100 mg碧容健有助于以统计学上显着的方式减少钙拮抗剂硝苯地平的剂量。与安慰剂相比，碧容健（R）的摄入显着降低了内皮素1的浓度，而与安慰剂相比，血浆中的6-酮基前列腺素F1a的浓度则明显更高。两组血浆中一氧化氮（NO）值均增加，但差异不显着。与碧容健组相比，安慰剂组血浆中血管紧张素II的浓度降低的程度更大。两组患者的治疗期间心率，电解质和血尿素氮均未改变。在两组中观察到的不良影响都是轻度和短暂的，例如胃肠道问题，眩晕，头痛和恶心。两组之间的副作用发生率差异无统计学意义。研究结果表明，对于轻度高血压患者，可以补充碧容健®。 （C）2003 Elsevier Inc.保留所有权利。 [参考：9]

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