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首页> 外文期刊>Life sciences >Interleukin-18 induces serum amyloid A (SAA) protein production from rheumatoid synovial fibroblasts
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Interleukin-18 induces serum amyloid A (SAA) protein production from rheumatoid synovial fibroblasts

机译：白细胞介素18诱导类风湿性滑膜成纤维细胞产生血清淀粉样蛋白A（SAA）

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摘要

Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patients with rheumatoid arthritis (RA) and 13 patients with osteoarthritis.(OA).,The levels of IL-18 and SAA in the synovial fluids were elevated in RA patients. In contrast, the levels of IL-18 in synovial fluids from. OA patients were significantly lower compared to those of RA patients. SAA was not detected in synovial fluids from. patients. The expression of SAA mRNA in rheumatoid synovial cells was also examined. SAA4 mRNA, which was constitutively expressed by rheumatoid synovial cells, was not affected by IL-18 stimulation. Although acute phase SAA (A-SAA, SAA1 + 2) mRNA was not detected in unstimulated synovial cells, its expression was induced,by IL-18 stimulation. By immunoblot, we demonstrated that IL-18 induced the SAA protein synthesis from rheumatoid synovial cells in a dose-dependent manner. These results indicate a novel role for IL- 18 in rheumatoid inflammation through the synovial SAA production. (C) 2003 Elsevier Inc., All rights reserved. [References: 16]
机译：白介素-18（IL-18）是一种新型促炎细胞因子，最近在类风湿关节炎（RA）患者的滑液和滑膜组织中发现。为了研究IL-18在类风湿性滑膜炎中的作用，在24例类风湿关节炎（RA）和13例骨关节炎（OA）患者的滑液中测量了IL-18和血清淀粉样蛋白A（SAA）的水平。 RA患者滑膜液中IL-18和SAA的水平升高。相反，滑液中IL-18的水平来自。与RA患者相比，OA患者显着降低。在滑液中未检测到SAA。耐心。还检查了类风湿性滑膜细胞中SAA mRNA的表达。由类风湿滑膜细胞组成性表达的SAA4 mRNA不受IL-18刺激的影响。尽管在未刺激的滑膜细胞中未检测到急性期SAA（A-SAA，SAA1 + 2）mRNA，但其表达是通过IL-18刺激诱导的。通过免疫印迹，我们证明IL-18以剂量依赖的方式诱导类风湿性滑膜细胞合成SAA蛋白。这些结果表明IL-18通过滑膜SAA产生在类风湿性炎症中的新作用。 （C）2003 Elsevier Inc.，保留所有权利。 [参考：16]

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