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首页> 外文期刊>Cell and Tissue Research >Transient up- and down-regulation of expression of myosin light chain 2 and myostatin mRNA mark the changes from stratified hyperplasia to muscle fiber hypertrophy in larvae of gilthead sea bream (Sparus aurata L.)
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Transient up- and down-regulation of expression of myosin light chain 2 and myostatin mRNA mark the changes from stratified hyperplasia to muscle fiber hypertrophy in larvae of gilthead sea bream (Sparus aurata L.)

机译：短暂性上调和下调肌球蛋白轻链2和myostatin mRNA的表达标志着金头鲷（Sparus aurata L.）幼虫从分层增生到肌纤维肥大的变化。

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摘要

Hyperplasia and hypertrophy are the two mechanisms by which muscle develops and grows. We study these two mechanisms, during the early development of white muscle in Sparus aurata, by means of histology and the expression of structural and regulatory genes. A clear stage of stratified hyperplasia was identified early in the development of gilthead sea bream but ceased by 35 dph when hypertrophy took over. Mosaic recruitment of new white fibers began as soon as 60 dph. The genes mlc2a and mlc2b were expressed at various levels during the main phases of hyperplasia and hypertrophy. The genes myog and mlc2a were significantly up-regulated during the intensive stratified formation of new fibers and their expression was significantly correlated. Expression of mstn1 and igf1 increased at 35 dph, appeared to regulate the hyperplasia-to-hypertrophy transition, and may have stimulated the expression of mlc2a, mlc2b and col1a1 at the onset of mosaic hyperplasia. The up-regulation of mstn1 at transitional phases in muscle development indicates a dual regulatory role of myostatin in fish larval muscle growth.
机译：增生和肥大是肌肉发育和成长的两种机制。我们通过组织学以及结构和调节基因的表达，研究了金头鲷白肌早期发育中的这两种机制。在金头鲷的发育早期，已经确定了一个清晰的分层增生阶段，但是当肥大接管时，这种增生阶段以35 dph停止。新的白色纤维的马赛克募集开始于60 dph。基因mlc2a和mlc2b在增生和肥大的主要阶段以不同水平表达。在密集分层形成新纤维的过程中，myog和mlc2a基因显着上调，并且它们的表达显着相关。在35 dph时，mstn1和igf1的表达增加，似乎调节了增生到肥大的过渡，并且可能在镶嵌增生开始时刺激了mlc2a，mlc2b和col1a1的表达。在肌肉发育的过渡阶段，mstn1的上调表明肌生长抑制素在鱼幼虫肌肉生长中具有双重调节作用。

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