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首页> 外文期刊>Life sciences >Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats.
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Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats.

机译：大蒜和姜黄的膳食补充剂的抗动脉粥样硬化作用：大鼠内皮功能的恢复。

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Protections of endothelial integrity by elimination of certain risk have proven to be effective in maintaining hemostasis and in slowing the progress of the cardiovascular disease. Indigenous drugs are the natural source of protection against these disorders, which can be used more effectively by the knowledge of their active ingredients as well as by their mechanism of action. Most prominent among these drugs are garlic, [Alium sativum L., Family: Liliaceae, Bulbs] and turmeric [Curcuma longa L., Family: Zingiberaceae, Rhizomes]; commonly used Indian traditional spices. In the present study, we examined the atheroscleroprotective potential of diet supplementation of garlic and turmeric by measuring serum lipid profile, changes in cardiovascular parameters i.e. arterial blood pressure, electrocardiogram and heart rate. We further tried to elucidate the mechanism of restoration of endothelial function and the role of endothelium-derived factors mainly, nitric oxide (NO) and cycloxygenase derived contracting factors. A notable restoration of arterial blood pressure was seen in animals on garlic and turmeric supplemented diet. Animals on supplemented diet showed a significantly enhanced vasorelaxant response to adenosine, acetylcholine, isoproterenol and contractile effect of 5-hyderoxytryptamine was significantly attenuated. Inhibition of these responses by L-NMMA was smaller in tissues from herbal treated animals. Incubation of tissues with L-arginine (10(-5) M) resulted in a significant reversal of L-NMMA induced inhibition of endothelium-mediated relaxation, which appeared to be pronounced in rings from animals supplemented with herbs as compared to hypercholesterolemic animals. Addition of indomethacin (10(-)(5) M) augmented the relaxation in all the groups of animals. The present study demonstrated that garlic and turmeric are potent vasorelaxants as well as reduce the atherogenic properties of cholesterol. Whether combination of these vasodilators in cardiovascular disorders with increased peripheral vascular resistance remains to be determined.
机译：通过消除某些风险来保护内皮完整性已被证明在维持止血和减缓心血管疾病进展方面是有效的。土著药物是预防这些疾病的天然来源，可以通过了解其有效成分及其作用机理来更有效地使用它们。这些药物中最突出的是大蒜，[大蒜，家族：百合科，鳞茎]和姜黄[姜黄，家族，姜科，根茎];常用的印度传统香料。在本研究中，我们通过测量血清脂质分布，心血管参数（即动脉血压，心电图和心率）的变化来检查补充大蒜和姜黄的饮食对动脉粥样硬化的保护作用。我们进一步试图阐明内皮功能恢复的机制以及内皮衍生因子（一氧化氮（NO）和环氧合酶衍生的收缩因子）的作用。在补充大蒜和姜黄的饮食中，动物的动脉血压明显恢复。补充饮食的动物对腺苷，乙酰胆碱，异丙肾上腺素的血管舒张反应显着增强，并且5-羟色胺的收缩作用显着减弱。在草药治疗的动物组织中，L-NMMA对这些反应的抑制作用较小。用L-精氨酸（10（-5）M）孵育组织导致L-NMMA诱导的内皮介导的舒张抑制作用的显着逆转，与高胆固醇血症动物相比，在补充草药的动物的环中似乎很明显。消炎痛（10（-）（5）M）的添加增加了所有动物组中的放松。本研究表明，大蒜和姜黄是有效的血管松弛药，并能降低胆固醇的动脉粥样硬化特性。这些血管扩张药在心血管疾病中与周围血管阻力增加的结合是否尚待确定。

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