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首页> 外文期刊>Life sciences >High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.
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High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.

机译：自闭症儿童的高半胱氨酸水平和血清对氧磷酶1芳基酯酶活性低。

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Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine and other biomarkers in children with autism to corresponding values in age-matched healthy children. We measured total homocysteine (tHcy), vitamin B(12), paraoxonase and arylesterase activities of human paraoxonase 1 (PON1) in plasma and glutathione peroxidase (GPx) activity in erythrocytes from 21 children: 12 with autism (age: 8.29 +/- 2.76 years) and 9 controls (age: 8.33 +/- 1.82 years). We found statistically significant differences in tHcy levels and in arylesterase activity of PON1 in children with autism compared to the control group: 9.83 +/- 2.75 vs. 7.51 +/- 0.93 micromol/L (P < or =0.01) and 72.57 +/- 11.73 vs. 81.83 +/- 7.39 kU/L (P < or =0.005). In the autistic group there was a strongnegative correlation between tHcy and GPx activity and the vitamin B(12) level was low or suboptimal. In conclusion, our study shows that in children with autism there are higher levels of tHcy, which is negatively correlated with GPx activity, low PON1 arylesterase activity and suboptimal levels of vitamin B(12).
机译：自闭症是一种病因不明的行为定义疾病，据认为受遗传和环境因素影响。高水平的半胱氨酸和氧化应激通常与神经精神疾病有关。这项研究的目的是将自闭症儿童的同型半胱氨酸和其他生物标记物的水平与年龄匹配的健康儿童中的相应值进行比较。我们测量了21名儿童（其中12名患有自闭症）的儿童血浆中人对氧磷酶1（PON1）的总同型半胱氨酸（tHcy），维生素B（12），对氧磷酶和芳基酯酶的活性以及血浆中的谷胱甘肽过氧化物酶（GPx）活性（年龄：8.29 +/- 2.76年）和9个对照（年龄：8.33 +/- 1.82年）。我们发现自闭症儿童的tHcy水平和PON1芳基酯酶活性与对照组相比有统计学差异：9.83 +/- 2.75 vs. 7.51 +/- 0.93 micromol / L（P <或= 0.01）和72.57 + / -11.73与81.83 +/- 7.39 kU / L（P <或= 0.005）。在自闭症组中，tHcy和GPx活性之间呈强负相关，而维生素B（12）含量较低或不理想。总之，我们的研究表明，自闭症儿童的tHcy水平较高，与GPx活性，低PON1芳基酯酶活性和维生素B欠佳水平负相关（12）。

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