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首页> 外文期刊>Life sciences >Immobility response elicited by clamping the neck induces antinociception in a 'tonic pain' test in mice.
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Immobility response elicited by clamping the neck induces antinociception in a 'tonic pain' test in mice.

机译：通过夹紧脖子引起的不动反应在小鼠的“强直性疼痛”试验中诱导抗伤害感受。

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Clamping the neck followed by body inversion to a supine position in mice elicits an immobility response called immobility by clamping the neck (ICN). The noxious pinch to the scruff of the neck produces antinociception in "phasic pain" models (e.g. tail-flick test). Here, a "tonic pain" model was used to test the antinociception associated with the ICN, and naloxone was used to determine the role of opioids in such antinociception. Mice were injected intraperitoneally with 0.3 mL of 0.4% acetic acid to produce writhing responses that were measured for one hour. ICN was induced every five minutes for one hour. Naloxone (5 mg/kg ip) was injected 10 min before acetic acid administration. There was a control group, sham clamping (SCLA). These mice were handled and restricted every five minutes as in the ICN but without real clamping. The repetitive inductions of ICN were able to reduce the writhing behavior; this antinociception was blocked by the naloxone pretreatment. In the SCLA group antinociception was not observed. These findings indicate that as in the "phasic pain" model, ICN also was able to elicit antinociception in this "tonic pain" model, and such antinociception seems to be mediated by opioids.
机译：夹住脖子，然后身体反转到小鼠的仰卧位置，会通过夹住脖子（ICN）引发一种称为不动的不动反应。在“阶段性疼痛”模型中（例如，甩尾试验），有害的颈ch捏会产生抗伤害感受。在这里，“强直性疼痛”模型用于测试与ICN相关的镇痛作用，而纳洛酮用于确定阿片类药物在此类镇痛作用中的作用。给小鼠腹膜内注射0.3mL的0.4％乙酸以产生扭体反应，该反应被测量一小时。每五分钟诱导一次ICN，持续一小时。服用乙酸前10分钟注射纳洛酮（5 mg / kg ip）。有一个对照组，即假手术（SCLA）。像在ICN中一样，每五分钟对这些小鼠进行处理和约束，但没有真正的夹紧。 ICN的重复诱导能够减少扭曲行为。纳洛酮预处理可阻止这种抗伤害感受。在SCLA组中未观察到抗伤害感受。这些发现表明，如同在“阶段性疼痛”模型中一样，ICN也能够在这种“张力性疼痛”模型中引发镇痛作用，并且这种镇痛作用似乎是由阿片类药物介导的。

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