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Effect of repetitive ischemic preconditioning on spinal cord ischemia in a rabbit model

机译：重复缺血预处理对兔模型脊髓缺血的影响

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A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation group, Group II: ischemic reperfusion group, and, Group III: IPC group. Spinal cord ischemia was induced by infra-renal aortic cross-clamp for 45 min in Group II. Before 45 min ischemia, the rabbits in Group III underwent four cycles of IPC (5 min of ischemia followed by 5 min of reperfusion). Post-operative neurological function, electromyography (EMG) of rear limbs, and spinal cord histopathological changes were measured. The concentrations of calcium, magnesium, copper, and zinc in spinal cord were measured in the 7th day. The neurological function and histopathological changes in Group II were significantly different from those in Group I or Group III (P < 0.05 or 0.01). There was a more significant change of EMG in Group II than that in Group III (P < 0.05). The concentrations of calcium and copper in Group H were sigificantly higher (P < 0.05 or 0.01), but magnesium and zinc were significantly lower (P < 0.05) than those in Group I. Calcium and copper in Group H were significantly higher (P < 0.05), but zinc was significantly lower (P < 0.01) than those in Group III. In conclusion, repetitive IPC can protect rabbit spinal cord from ischemic reperfusion injury in a timely manner, which is associated with corrections of imbalance of calcium, magnesium, copper, and zinc in the ischemic region. (c) 2006 Elsevier Inc. All fights reserved.
机译：设计了基于兔模型的完全随机对照研究，以研究重复缺血预处理（IPC）对脊髓缺血再灌注损伤的影响。将24只成年日本白兔随机分为3组（每组8只）之一：第一组：假手术组，第二组：缺血再灌注组，第三组：IPC组。第二组中通过肾下主动脉交叉钳夹诱导脊髓缺血45分钟。在缺血45分钟之前，第III组的兔子经历了四个IPC周期（缺血5分钟，再灌注5分钟）。测量术后神经功能，后肢肌电图（EMG）和脊髓组织病理学变化。在第7天测量脊髓中钙，镁，铜和锌的浓度。第二组的神经功能和组织病理学变化与第一组或第三组显着不同（P <0.05或0.01）。与第二组相比，第二组的肌电图变化更为显着（P <0.05）。 H组中钙和铜的浓度明显较高（P <0.05或0.01），而镁和锌的含量却显着低于I组（P <0.05）。H组的钙和铜含量则较高（P <0.05 0.05），但锌显着低于第三组（P <0.01）。总之，重复IPC可以及时保护兔脊髓免受缺血性再灌注损伤，这与纠正缺血区域中钙，镁，铜和锌的失衡有关。 （c）2006 Elsevier Inc.保留所有战斗权。

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