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Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp

机译：虾青素改善SHR / NDmcr-cp代谢综合征的特征

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Glucose and lipid metabolic parameters play crucial roles in metabolic syndrome and its major feature of insulin resistance. This study was designed to investigate whether dietary astaxanthin oil (ASX-O) has potential effects on metabolic syndrome features in an SHR/NDmcr-cp (cp/cp) rat model. Oral administration of ASX (50 mg/kg/day) for 22 weeks induced a significant reduction in arterial blood pressure in SHRcp. It also significantly reduced the fasting blood glucose level, homeostasis index of insulin resistance (HOMA-IR), and improved insulin sensitivity. The results also showed an improved adiponectin level, a significant increase in high-density lipoprotein cholesterol, a significant decrease in plasma levels of triglycerides, and non-esterified fatty acids. Additionally, ASX showed significant effects on the white adipose tissue by decreasing the size of the fat cells. These results suggest that ASX ameliorates insulin resistance by mechanisms involving the increase of glucose uptake, and by modulating the level of circulating lipid metabolites and adiponectin. (c) 2006 Elsevier Inc. All rights reserved.
机译：葡萄糖和脂质代谢参数在代谢综合征及其胰岛素抵抗的主要特征中起关键作用。这项研究旨在调查饮食中的虾青素油（ASX-O）是否对SHR / NDmcr-cp（cp / cp）大鼠模型的代谢综合征特征具有潜在影响。口服ASX（50 mg / kg /天）22周可导致SHRcp的动脉血压显着降低。它还显着降低了空腹血糖水平，胰岛素抵抗动态平衡指数（HOMA-IR）和改善的胰岛素敏感性。结果还显示脂联素水平得到改善，高密度脂蛋白胆固醇显着增加，甘油三酸酯和非酯化脂肪酸的血浆水平显着下降。另外，ASX通过减少脂肪细胞的大小对白色脂肪组织显示出显着效果。这些结果表明，ASX通过涉及增加葡萄糖摄取的机制以及通过调节循环脂质代谢产物和脂联素的水平来改善胰岛素抵抗。 （c）2006 Elsevier Inc.保留所有权利。

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