• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Response to citalopram is not associated with SLC6A4 genotype in African-Americans and Caucasians with major depression
【24h】

Response to citalopram is not associated with SLC6A4 genotype in African-Americans and Caucasians with major depression

机译：在严重抑郁症的非洲裔美国人和高加索人中，对西酞普兰的反应与SLC6A4基因型无关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims Ethnic differences in genotype frequency provide a natural condition for assessing the contribution of gene variations to the causes and treatments of disease. Accordingly, the purpose of this study was to determine whether ethnic variations in allele frequencies of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) of the SLC6A4 gene were related to the response to the treatment of depression. Main methods African-Americans (n = 101) and Caucasians (n = 100) with major depressive disorder were treated with the antidepressant citalopram (20-60 mg/day) for 8 weeks. Genotyping for the long (L) and short (s) alleles (LL, Ls, and ss) of the SLC6A4 gene was performed and the association between genotype and treatment response was assessed. Key findings Subjects in both ethnic groups showed a significant reduction in depression scores over time (p <.0001). However, in spite of a significantly greater frequency of the L allele in African-Americans as compared to Caucasians, a comparable clinical response between the two groups was found with 5-HTTLPR polymorphism not significantly associated with clinical response in either ethnic group. Significance The results are consistent with a previous finding and in accord with most of the results obtained in Caucasian subjects that SLC6A4 genotype is not related, at least by itself, to a response to treatment in either ethnic group to any clinically significant degree.
机译：目的基因型频率的种族差异为评估基因变异对疾病原因和治疗的贡献提供了自然条件。因此，本研究的目的是确定SLC6A4基因的血清素转运蛋白基因连接的多态性区域（5-HTTLPR）等位基因频率的种族差异是否与抑郁症的治疗反应有关。主要方法用抗抑郁药物西酞普兰（20-60 mg /天）治疗患有严重抑郁症的非裔美国人（n = 101）和白种人（n = 100），持续8周。对SLC6A4基因的长（L）和短（s）等位基因（LL，Ls和ss）进行基因分型，并评估基因型与治疗反应之间的关联。主要发现这两个种族的受试者的抑郁评分均随着时间的推移而显着降低（p <.0001）。然而，尽管与白种人相比，非裔美国人中L等位基因的频率明显更高，但发现两组中具有可比的临床反应，且5-HTTLPR多态性与任一种族中的临床反应均无显着相关性。重要性该结果与先前的发现相符，并且与在白种人受试者中获得的大多数结果一致，即SLC6A4基因型至少在任何方面都与临床上任何一个种族的治疗反应均无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号