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首页> 外文期刊>Life sciences >Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2
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Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2

机译：地塞米松诱发的大鼠高血压相关神经元Fos样免疫反应和胰高血糖素样肽2的作用

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Aims Dexamethasone-induced hypertension models have been used to study the mechanisms of glucocorticoid-induced hypertension, but the role of glucocorticoids in central cardiovascular regulation is not clearly understood. In the present study, we investigated the sites associated with dexamethasone-induced hypertension in the central nervous system in rats. We further investigated whether glucagon-like peptide-2 (GLP-2) was effective for dexamethasone-induced hypertension. Main methods Male Sprague-Dawley rats were treated with saline or dexamethasone (0.03 mg/kg/day, s.c) for 10 days. GLP-2 (60 μg/kg, i.v.) was given to rats after dexamethasone treatment. We measured systolic blood pressure by a tail-cuff method in conscious rats, and arterial blood pressure in anesthetized rats. Immunohistochemical techniques were used to detection of the c-fos protein (Fos). Key findings Fos-immunoreactivity (Fos-IR) in the dorsomedial hypothalamic nucleus (DMH) was higher in dexamethasone-treated rats than in saline-treated rats. However, Fos-IR in the infralimbic cortex, amygdala, and hippocampus was similar in saline-treated and dexamethasone-treated rats. Peripheral administration of GLP-2 reduced mean arterial blood pressure by 26%. After the peripheral administration of GLP-2, Fos-IR in the caudal ventrolateral medulla (CVLM) increased in dexamethasone-treated rats. Significance Chronic dexamethasone treatment induced Fos-IR in the DMH. Peripheral administration of GLP-2 suppressed dexamethasone-induced hypertension in rats by enhancing inhibitory neuronal activity.
机译：目的地塞米松诱导的高血压模型已用于研究糖皮质激素诱导的高血压的机制，但糖皮质激素在中枢心血管调节中的作用尚不清楚。在本研究中，我们调查了地塞米松诱发的大鼠中枢神经系统高血压的相关部位。我们进一步研究了胰高血糖素样肽2（GLP-2）是否对地塞米松诱发的高血压有效。主要方法用盐水或地塞米松（0.03 mg / kg /天，皮下注射）治疗雄性Sprague-Dawley大鼠10天。地塞米松处理后，将GLP-2（60μg/ kg，静脉内）给予大鼠。我们通过尾袖法在清醒大鼠中测量了收缩压，在麻醉大鼠中测量了动脉血压。免疫组织化学技术用于检测c-fos蛋白（Fos）。主要发现地塞米松治疗组大鼠下丘脑下丘脑核（DMH）中的Fos免疫反应性（Fos-IR）高于生理盐水治疗组。但是，在盐水处理和地塞米松处理的大鼠中，下肢皮质，杏仁核和海马中的Fos-IR相似。外周给予GLP-2可使平均动脉血压降低26％。在外周给予GLP-2后，地塞米松治疗的大鼠尾侧腹外侧延髓（CVLM）中的Fos-IR升高。慢性地塞米松治疗可引起DMH中的Fos-IR。通过增强抑制性神经元活性，外周给药GLP-2可抑制地塞米松诱发的大鼠高血压。

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