• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Sexual dimorphism in fat distribution and metabolic profile in mice offspring from diet-induced obese mothers
【24h】

Sexual dimorphism in fat distribution and metabolic profile in mice offspring from diet-induced obese mothers

机译：饮食诱导的肥胖母亲的小鼠后代的脂肪分布和代谢特征的性别差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims To investigate whether the effects of diet-induced obesity in mothers are passed on to their offspring fed a control diet in a gender-specific manner. Main methods Mother mice received either standard chow (SC; 17% energy from fat) or high-fat (HF; 49% energy from fat) diet for eight weeks pre-pregnancy until lactation. After weaning (at 21 days of age), offspring received SC diet and were divided into four groups according to the mother's diet (Mo): male Mo-SC, female Mo-SC, male Mo-HF, and female Mo-HF. Stereology, Elisa and western blotting were performed. Key findings HF diet-fed mothers were overweight, and had metabolic abnormalities, all of which were found in their adult offspring. Male Mo-HF offspring had higher cholesterol, triglycerides, leptin and insulin levels and lower circulating adiponectin than female Mo-HF offspring. Mo-HF offspring of both genders had higher expression of tumor necrosis factor-alpha, interleukin-6 and leptin and lower expression of adiponectin than Mo-SC offspring; however, male Mo-HF were more affected than female Mo-HF offspring for these variables, demonstrating sexual dimorphism. Significance Exposure to HF diet is effective in inducing obesity and metabolic alterations in mothers, and this phenotype can be passed on to their offspring. An adverse pattern in the body fat distribution in males probably has favored the intensification of a pro-inflammatory profile compared with females. In adulthood, the male offspring responds to the maternal obesity more than the female offspring, indicating a relevant sexual dimorphism that is a novel finding in this animal study.
机译：目的探讨饮食中肥胖对母亲的影响是否以特定性别的方式传递给以对照饮食喂养的后代。主要方法母鼠在怀孕前八周接受标准食物（SC; 17％的脂肪能量）或高脂饮食（HF; 49％的脂肪能量）饮食，直到怀孕前八周。断奶后（21日龄），后代接受SC饮食，并根据母亲的饮食（Mo）分为四组：雄性Mo-SC，雌性Mo-SC，雄性Mo-HF和雌性Mo-HF。进行了体视学，Elisa和蛋白质印迹。主要发现高脂饮食喂养的母亲超重，并有代谢异常，所有这些都在成年后代中发现。雄性Mo-HF的后代比雌性Mo-HF的后代具有更高的胆固醇，甘油三酸酯，瘦素和胰岛素水平，而循环脂联素则较低。 Mo-HF后代均比Mo-SC后代高表达肿瘤坏死因子-α，白介素-6和瘦素，脂联素则低表达。然而，由于这些变量，男性Mo-HF比女性Mo-HF后代受到的影响更大，这表明性二态性。重要性暴露于HF饮食可以有效地诱发母亲的肥胖和代谢改变，并且该表型可以传给其后代。与女性相比，男性体内脂肪分布的不利模式可能有利于增强促炎性。成年后，雄性后代对雌性肥胖的反应比雌性后代更多，表明相关的性二态性是这项动物研究中的新发现。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号